tag:blogger.com,1999:blog-3045634714760830992.post9057338289385249454..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Alzheimer's Disease and Saturated Fat - Is Butter Part of the Recipe for Dementia?Anonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-3045634714760830992.post-75958120266450777182013-07-31T09:05:53.855-04:002013-07-31T09:05:53.855-04:00A couple of points...
humans are not rodents. Any...A couple of points...<br /><br />humans are not rodents. Any studies done on rodents are irrelevant to humans as we evolved to eat completely different diets.<br /><br />Humans start developing Alzheimer's mainly at our life's end stages. There's no reason for evolution to select out a tendency to geriatic Alzheimer's as we don't breed, or care for grandchildren after 70, at least not historically. We are defunct dead ends by this stage and there's no reason for evolution to have adapted to protect us after our contribution to childcare is over.mathildahttps://www.blogger.com/profile/06682429587184048584noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-31895161917702246692013-05-23T20:57:01.281-04:002013-05-23T20:57:01.281-04:00I just read that one in ten cats has dementia
http...I just read that one in ten cats has dementia<br />http://www.telegraph.co.uk/news/2489723/One-in-ten-cats-has-dementia.html<br /><br />50% of cats over 15<br />25% of cats 11-14<br />Researchers from the University of Edinburgh now believe half of all cats over the age of 15 and a quarter aged 11 to 14, are suffering from "geriatric onset behavioural problems". <br /><br />Maybe we should be looking at what they eat. Are cat pellets high in carbs unsaturated fat? Also, a 100% processed diet is not going to protect your brain.Anonymoushttps://www.blogger.com/profile/16415461725173533976noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-24775412496717513252013-05-22T23:54:01.339-04:002013-05-22T23:54:01.339-04:00Are they possibly using low quality saturated fat ...Are they possibly using low quality saturated fat sources? If the study doesn't explicitly state that they used <br />Poor quality saturated fats include hydrogenated coconut oil <br />or grain fed beef (actually contains much higher levels of unsaturated oils), instead of grass fed.Anonymoushttps://www.blogger.com/profile/16415461725173533976noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-13492688444715372392012-05-13T17:02:00.044-04:002012-05-13T17:02:00.044-04:00This is very interesting information. I'm alw...This is very interesting information. I'm always trying to figure out what to eat to reduce Alzheimer's risk.Anonymoushttps://www.blogger.com/profile/15787417321539228927noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-18519703061308163032010-10-18T20:24:16.467-04:002010-10-18T20:24:16.467-04:00Thanks Julianne. Dr Su talks about MCT oil and typ...Thanks Julianne. Dr Su talks about MCT oil and type 3 diabetes in our podcast interview (should go live 12/15)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-86680294640455072322010-10-17T19:45:13.494-04:002010-10-17T19:45:13.494-04:00Hi Emily,
I wondered if you had seen this on Jimmy...Hi Emily,<br />I wondered if you had seen this on Jimmy Moore's blog, the story of a man who appears to have reversed Alzheimers with diet and supplements<br />http://livinlavidalowcarb.com/blog/can-you-heal-alzheimers-with-diet-and-supplements-nita-scoggan-did/8782juliannehttps://www.blogger.com/profile/13708012296463731739noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-50070477571014912712010-10-17T14:27:34.794-04:002010-10-17T14:27:34.794-04:00Tom - thanks for the interesting links! What I fi...Tom - thanks for the interesting links! What I find in the alzheimer's literature is that the body seems to have a lot of ways to metabolize amyloid and APP - we don't have all these chemicals unless the are important for something! Amyloid may be the brain's version of cholesterol - and just as understood. <br /><br />Bryan - thanks, great study. I haven't had a chance to chase down the rat chow in those high sat fat vs low fat from the review article - something tells me there isn't a low carb option there! The answers are always found in the rat chow. I've learned a little bit from Hyperlipid.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-57653223597201827512010-10-17T14:05:47.673-04:002010-10-17T14:05:47.673-04:00Hah - Nick - I just read that WAPF blog - "a ...Hah - Nick - I just read that WAPF blog - "a new kind of observational study, one that can't be used for anything.". I think he gets it right! Sad thing is all mental health and diet studies seem to be these dietary pattern disasters! <br /><br />Malpaz - I doubt it. I would doubt that physiologic insulin resistance has anything to do with reducing fertility. In the case of PCOS, a low carb diet is key to improving metabolic function and fertility. Pathological insulin resistance is a part of infertility, however, as examples by lower fertility among diabetics and those with PCOSAnonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-26328699952013180672010-10-17T13:07:25.280-04:002010-10-17T13:07:25.280-04:00"Stepping back to the big picture, please rem..."Stepping back to the big picture, please remember that "fat-induced insulin resistance" is physiologic, not pathologic. It is one of the ways a body adapts to a low carb diet."<br /><br />alzheimers aside...would this quote/fact be a possible link for a inhibitiion of fertility(as i am trying to regai my period) eating high fat lower carb?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-67515306678973049352010-10-17T09:59:19.117-04:002010-10-17T09:59:19.117-04:00Hey Emily, have you seen this study:
http://www.nu...Hey Emily, have you seen this study:<br />http://www.nutritionandmetabolism.com/content/2/1/28<br /><br />they actually tested a low carb ketogenic diet in an Alzheimer's mouse modelBryan B.https://www.blogger.com/profile/04330347371318190480noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-66576100847590622962010-10-17T08:44:20.852-04:002010-10-17T08:44:20.852-04:00Further info about the anti-microbial effects of a...Further info about the anti-microbial effects of amyloid beta from PLoS The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide<br /> http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009505<br /><br />See good commentary by Derek Lowe here: http://pipeline.corante.com/archives/2010/03/16/betaamyloid_an_antibiotic.php<br /><br />To further contribute to the confusion see this PLoS article about the UV protrective effects of amyloid here:"The Unfolding of Amyloid's True Colors" http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0040008Tom Garnetthttps://www.blogger.com/profile/05564496319301664839noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-39881065927138343362010-10-17T07:47:40.028-04:002010-10-17T07:47:40.028-04:00Good morning all - Thanks for the heads up to the...Good morning all - Thanks for the heads up to the WAPF link. But I don't get too concerned about these epidemiological studies, as they always ultimately compare the "I don't give a crap about my health" people to the "I care and I eat salads" people. They can account for all the confounders they want, but you will never get them all. That is why those Australian diet and mood disorders studies are so interesting (though still similarly limited) - they have the "western", "traditional" AND "modern" diets, so they seem to account for the health magazine subscription holders, and western and modern diets were found wanting in those studies. <br /><br />In other words, I'll keep eating my pasture butter. (there are some really funny studies about pasture butter. It's not really psych but maybe Ill chat about one sometime. The researchers fall all over themselves to talk about how the CLA must magically undo all the bad things about the saturated fat in the butter. It's hysterical)<br /><br />Paul - I've read several review papers on saturated fat (or dietary fat) and Alzheimer's and they are all like is one, though this one has more nitty gritty biochem, which is why I'm focusing on it. There was one that even remarked how important cholesterol is in the synapse, then jumped back to defending the lipid hypothesis. This paper has a whole section on cholesterol that I left out as too confusing - amyloid-experiment rabbits who eat cholesterol get choked up with plaque in arteries and amyloid plaque, but in mice, dietary cholesterol seemed to reduce some of the amyloid beta in the chylomicron floating around shenanigans. The researchers went back and forth, finally admitting it was just "complicated". I do find your infectious agent theory intriguing. Seems like we must have a good reason to make the amyloid. <br /><br />Porcupine - not sure what kind of butter the subjects ate. Maybe some of them were in the paleo interest group in NYC? ;)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-67129714272501452012010-10-17T03:09:33.605-04:002010-10-17T03:09:33.605-04:00The subjects most likely ate butter made from cows...The subjects most likely ate butter made from cows that lived in feedlots, ate grain, got antibiotics, maybe growth hormones. The milk was pasteurised and homogenised and who knows what else before it was made into butter. Traditionally made butter from grassfed cows might have a different affect on the body and brain.Ruth Almonhttps://www.blogger.com/profile/06152621096734252062noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-73779259757094381642010-10-16T23:30:13.460-04:002010-10-16T23:30:13.460-04:00A lot of nice posts in this Alzheimer's series...A lot of nice posts in this Alzheimer's series, Emily. <br /><br />I've been planning to comment on some of them, arguing that the alternative hypothesis of an infectious origin for Alzheimer's can explain a lot of these phenomena.<br /><br />For instance, C. pneumoniae, which is the most likely agent for Alzheimer's, infects blood vessels in the brain first and spreads to neurons and glial cells after generating apoptosis in endothelial cells. So that helps explain the compromised blood-brain barrier.<br /><br />Amyloid is an antimicrobial peptide, which explains a lot.<br /><br />A lot of non-sequiturs in today's paper. Sounds like free association more than reasoning.Paul Jaminethttps://www.blogger.com/profile/15122941682076992645noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-43194338242625246562010-10-16T23:14:04.540-04:002010-10-16T23:14:04.540-04:00The study you mention at the beginning of the post...The study you mention at the beginning of the post was already analyzed over at WAPF.<br /><br />http://www.westonaprice.org/blogs/reductionism-and-holism-go-hand-in-hand.html<br /><br />Just an interesting contrast.<br />LOVE this blog by the way!Nickhttps://www.blogger.com/profile/06984697251778927857noreply@blogger.com