tag:blogger.com,1999:blog-3045634714760830992.post6574754686049709692..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: B12 Deficiency and Psychosis, A Case StudyAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-3045634714760830992.post-2112940947196826852014-05-20T11:08:51.089-04:002014-05-20T11:08:51.089-04:00The day following my B12 injections, my mood was v...The day following my B12 injections, my mood was very low (depressed/weepy). For the following few days I felt like I was having pms symptoms--a lot of irritability and some cramping. I just read that high doses of B12 can cause folate levels to drop significantly. I've discontinued B12 shots for now until I get this figured out. What are your thoughts on this--do you think low folic acid could produce these effects?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19589400337570556172013-07-21T16:42:14.313-04:002013-07-21T16:42:14.313-04:00Nice. Congrats.Nice. Congrats.shtovehttps://www.blogger.com/profile/16109559722715781557noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-85126024655345915932013-06-16T09:50:52.325-04:002013-06-16T09:50:52.325-04:00Sorry to bang on about this, and it's not stri...Sorry to bang on about this, and it's not strictly psychiatric, but it is worthy of mention that my IBS resolved completely in the first week. And I haven't had a migraine since the first shot - after suffering with at least three a month, and ultimately three a week, by the time of the B12 diagnosis. Sanity and continence!Toxichttps://www.blogger.com/profile/02308852947261190129noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19993490741594053252013-05-28T21:57:30.240-04:002013-05-28T21:57:30.240-04:00I've got this. Seriously. Just been started on...I've got this. Seriously. Just been started on B12 shots, every other daily. Apart from the usual fatigue, weepiness, pins and needles etc. I had a permanent smell of woodsmoke in my nose. I could hear whole orchestras, let alone voices in my head. And I could taste nothing at all. I feel like I am wearing socks and gloves, and yet can't feel my real clothes on my skin. My aphasia is spectacular. I haven't been able to remember a noun for a long time, although I can write plenty! Recently, I called the TV "that box thing in the corner with morning people on it." I have coeliac disease. I've been diagnosed with pernicious anaemia, and am awaiting confirmation of Sub Acute Combined... etc. So perhaps this case isn't an unusual presentation at all. Mood back to normal (better than normal. Best ever) with the first shots. Absolutely shocking. Improvements all round, but some things not resolving and may never, I now find. Wonder how common this really is?Toxichttps://www.blogger.com/profile/02308852947261190129noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-17437879795130009442012-11-26T07:16:20.731-05:002012-11-26T07:16:20.731-05:00If you are not in touch with Dr Bransfield in NJ, ...If you are not in touch with Dr Bransfield in NJ, he runs a list focused on Microbes in Mental Illness that you would find alot of interesting information on.Aurorahttps://www.blogger.com/profile/03793897198521388432noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-75799721759402467122012-11-17T02:30:36.023-05:002012-11-17T02:30:36.023-05:00Chris Kresser has an article about B12, and how pe...Chris Kresser has an article about B12, and how people with IBD and IBS have B12 malabsorption for life (very few recover fully regarding this). Might be a good article to look at.<br /><br />I had IBS for 10 years, which started going away when I found Paleo. Fast forward many months later, and I went to a dermatologist about something unrelated, and he said he would check for B12 too. I almost told him not to, since I was eating meat/fish by the pound. I thought to myself: "what a useless test, with all this meat I eat". It turned out I was severely B12-deficient, and I was probably much worse when I had IBS. I couldn't believe it! IMHO, everyone with gut problems should be tested for B12. I semi-fixed it with B12 Cyanocobalamin pills, daily for 2 months. I got my range up to 1100, up from 380 (I expect to have spent many years below 200 while having IBS).Eugenia Lolihttps://www.blogger.com/profile/03841412747426733061noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-70111764174604689462012-11-14T13:45:03.497-05:002012-11-14T13:45:03.497-05:00Dr. Stasha Gominak emphasized the importance of vi...Dr. Stasha Gominak emphasized the importance of vitamin B12 in patients with sleep and headache problems (along with vitamin D). She recommends maintaining B12 levels of 600.<br />http://www.youtube.com/watch?v=h7cbBB1c0IM<br />Ralph Doncasterhttps://www.blogger.com/profile/00037504544742962130noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-44716036344382119022012-11-13T03:04:07.948-05:002012-11-13T03:04:07.948-05:00Low serum vitamin D concentrations in patients wit...Low serum vitamin D concentrations in patients with schizophrenia.<br />http://www.ima.org.il/imaj/ar12feb-04.pdf<br /><br />"We recruited 50 patients with schizophrenia and compared them to 33 patients with major depression and 50 controls with no major psychopathology. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia and the Hamilton Depression scale for depression were administered on the same day the blood samples were drawn. We used LIAISON 25-OH vitamin D (DiaSorin) immunoassay to measure serum concentrations of 25-OH vitamin D.<br />RESULTS:<br />Lower serum vitamin D concentrations were detected among patients with schizophrenia (15.0 +/- 7.3 ng/ml) compared to patients with depression (19.6 +/- 8.3 ng/ml) and to controls (20.2 +/- 7.8 ng/ml, P < 0.05). We found no correlation between disease activity, measured by the PANSS score, and vitamin D levels.<br />CONCLUSIONS:<br />Serum vitamin D levels were lower in patients with schizophrenia as compared to patients with depression and to healthy controls. No correlation was found between serum concentration and disease activity. Additional studies are needed to elucidate the role of vitamin D in the autoimmune mechanism and in the pathogenesis of schizophrenia."<br /><br />So 25-OH vit D is significantly lower in schizophrenics, correlates with the disease but not with active symptoms.<br />But what of 1,25(OH)2 D?<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-22508849014359181882012-11-12T18:28:25.671-05:002012-11-12T18:28:25.671-05:00Looks like he was double dipped because they did c...Looks like he was double dipped because they did celiac biopsies and gastric biopsies for H pylori, so they would have ruled out Crohns, Diphyllobothrium Latum (another nice boards question!). The point of the whole Schilling Test ordeal is to figure out if there is an intrinsic factor issue or where the B12 problems are occuring. Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-72147180688906326262012-11-12T02:18:18.976-05:002012-11-12T02:18:18.976-05:00To list the few other B12-deficiency etiologies th...To list the few other B12-deficiency etiologies that are immediately conjured up in the mind of a well-trained med student: pernicious anemia, D. latum infection, and Crohn's (the stomach is responsible for intrinsic factor production, but it's mostly absorbed in the terminal ileum). I see they did not test for antiparietal autoantibodies, but the others aren't addressed. I wonder how long ago his symptoms improved: I would think that significant B12 dosing could replete his liver stores, pushing the need for an etiology search back several months or years.<br /><br />Parts of his presentation are reminiscent of the symptoms I saw in severely malnourished women in the eating disorders unit, although clearly those women had many things going on. It reminds you how the effects of an eating disorder can perpetuate the problem.Angelahttps://www.blogger.com/profile/10670446798562054370noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-85430462268839853452012-11-12T01:39:41.368-05:002012-11-12T01:39:41.368-05:00Great pick up. One of the problems with B-12 is t...Great pick up. One of the problems with B-12 is that many labs have an equivocal range and in that case I have tested for homocysteine and methylmalonic acid, although the more it is studied the more equivocal it seems to be. I have not seen a Shilling Test done in a long time. The other learning point here as you have pointed out is the need for rapid B-12 replacement as was done in this case. I also see a lot of higher than average B-12 and folate levels in daily vitamin takers. George Dawson, MD, DFAPAhttps://www.blogger.com/profile/03474899831557543486noreply@blogger.com