tag:blogger.com,1999:blog-3045634714760830992.post1951361579833897371..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Diet and Dementia - A New StudyAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-3045634714760830992.post-52582054325761807632011-06-18T13:53:08.460-04:002011-06-18T13:53:08.460-04:00Hello! First-time reader! I really love your blog!...Hello! First-time reader! I really love your blog!<br /><br />QUESTION: I've heard there are links between diet and depression. If someone appears to have a genetic disposition to depression, what are some dietary changes that seem to help? I've heard that boosting protein (with all those amino acids) can help, but is this true and are there more changes you would recommend? Also, are there any supplements you would recommend?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-33023110747063736892011-06-18T06:07:14.952-04:002011-06-18T06:07:14.952-04:00Js290 - hah! Fortunately I have nothing to prove ...Js290 - hah! Fortunately I have nothing to prove - as one of the shortest, smallest, and newest crossfitters at the box, my scores will never be competitive (except with myself). BUT, prior to having kids, I spent many, many years working out very regularly, several times with personal trainers, and never have I been able to build strength so quickly or get such obvious changes in muscles so quickly as with crossfit. While I had worked out with BFL nutrition before, I've never worked out very seriously eating Paleo before joining crossfit, so that may be the difference. For the past 5 years I've been doing sprints and weights at home, but rarely lifting anything heavier than 20 lbs (except the kids - now 40 and 32 lbs). I believe I've been crossfitting six weeks at this point - and a total of 9 workouts, and it's really quite amazing the strength gains and differences in arms and toning of the midsection and whatnot. <br /><br />Allison - maybe in three years I'll be able to do a ring dip :-)<br /><br />Mario - Thanks for your question - many of my patients are not interested in dietary changes either - I'm really looking forward to the podcast. The HIGH diet was 35-40% carb and 45% fat, high GI carbs at that - I'm guessing you could very readily increase IR with enough sugar in there. <br /><br />Gobbledy-gook- The authors certainly thought the LOW diet (high carb, low fat) was better. I wanted to explore this paper for a couple of reasons - 1) It does show some interesting biomarker changes with different diets. 2) I'm hopeful the corresponding author gets back to me with more information about the actual diets, as it is, who knows what they were eating? I mean, palmitic is not stearic is not myristic is not lauric acid, yet all of those are dietary saturated fats. (See Jamie's recent post:"The failings of gross biochemistry" http://thatpaleoguy.blogspot.com/2011/05/failings-of-gross-biochemistry.html ) We do ourselves a HUGE disservice trying to sort out something as complex as dementia by throwing mere macronutrient ratios at it and trying to say - oh, yeah, saturated fat is bad and a low GI high carb diet is good. A low GI high carb diet will pretty much have to be quite a lot of "real" food - or a lot of fiber - and very readily drops the HDL and LDL within the month as you can see. 3) I saw this paper tweeted many times, and many links to news stories, given the press, I thought I ought to go more deeply into it. 4) The differences in how the aMCI patients responded to the dietary changes compared to the controls are interesting, demonstrating a biochemistry that has been altered in unexpected ways - perhaps a more brittle and extreme biochemistry that is very vulnerable.<br /><br />As it is, this paper has a lot of links that are interesting that I will be following, and if we do get more detailed info back about the diets, we can possibly learn something. <br /><br />As it is I feel the biomarkers show a mixed picture of the diets' effect on the MCI patients - is decreasing ApoE really a good thing? And the authors have a graph in the paper showing an "inflection point" prior to developing MCI symptoms - some of the biomarkers are low in young adults, then go up in the years leading to dementia, but once dementia starts, the biomarkers drop again. The authors seemed to feel that with some biomarkers, increasing would be "bad" in controls (putting you closer to the inflection point) and "good" in dementia (pushing you backwards closer to the inflection point) - and, sure, I guess you could make a case for that. Or you could say that they tortured a model to fit their data so the LOW diet comes out swimmingly.<br /><br />In the paper there is no detailed discussion of why a high sat fat diet would lead to the pathophysiology of dementia - they link to several papers (some of which I've already explored) but I will hunt them all down and post anything new. They seem to think sat fat is inflammatory. Weird, huh? :-)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-61821216174860731332011-06-17T20:42:24.618-04:002011-06-17T20:42:24.618-04:00I did not understand. A high carb diet is better?....I did not understand. A high carb diet is better?. If cholesterol does not cross the BBB how is it that some people sa that high fat is good because the brain is made of cholesterol?<br /><br />I think the best blogging service is https://posterous.com/ but blogger is supposed to last.<br /><br />Sorry to insist, but some bold words or sentences will help reading. At least those with bad sight and non native english speakers.<br /><br />Thanks.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-50846744767806464522011-06-17T13:12:05.645-04:002011-06-17T13:12:05.645-04:00I have been doing CrossFit for three years now. I...I have been doing CrossFit for three years now. I'm in the best shape of my life. It seems that I am meeting more and more doctors who have discovered the benefits of high-intensity cross training. The CrossFit community is also largely Paleo, which is where I discovered it.allisonhttps://www.blogger.com/profile/00035675984343369850noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-744987365172388392011-06-17T07:25:57.765-04:002011-06-17T07:25:57.765-04:00Since IR increased in HIGH, I bet that the other 2...Since IR increased in HIGH, I bet that the other 20% of fat was from healthy vegetable oil...<br /><br />QUESTION for your for this that will be the HOTTEST podcast EVER! As a husband of a brazilian psychiatrist, I see my wife struggling with patients. Almost none of them, even one with cancer, are willing to make changes in their diet. They all seek easy paths: pills. So, my question is: what are the medicine in psychiatry that you find is useless and the ones that you think can help (not a easy question, I suppose!).Mario Iwakurahttps://www.blogger.com/profile/15764058142849243458noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-1542870365000881652011-06-16T23:30:36.339-04:002011-06-16T23:30:36.339-04:00Sorry to hear you're doing Crossfit. :-PSorry to hear you're doing <a href="http://www.board.crossfit.com/forumdisplay.php?f=12" rel="nofollow">Crossfit.</a> :-Pjs290https://www.blogger.com/profile/08157385596237909630noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-45820544125192686532011-06-16T20:05:44.840-04:002011-06-16T20:05:44.840-04:00The diets were designed by a nutritionist--I'm...The diets were designed by a nutritionist--I'm surprised that either would promote health.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.com