tag:blogger.com,1999:blog-3045634714760830992.post7199591795545501653..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Glutathione: We Loves It (NAC and Autism)Anonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger50125tag:blogger.com,1999:blog-3045634714760830992.post-5350857699594885202015-02-11T06:17:39.166-05:002015-02-11T06:17:39.166-05:00Nah NAC is moreso. What we are really talking abo...Nah NAC is moreso. What we are really talking about here is the ability to detox acetaldehyde. Acetaldehyde is produced by candida. Candida is the real root cause of all these problems. Cystine does work to detox AA but NAC and ALA are much better. Here is a list from worst to best.<br />Vitamin C<br />cystine<br />b1-Thiamibe<br />nac<br />alaNatureHackerhttps://www.blogger.com/profile/02089364350909467465noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-38965570013287600362014-10-16T20:17:12.563-04:002014-10-16T20:17:12.563-04:00I am trying to get to the bottom of the question: ...I am trying to get to the bottom of the question: if someone has poor sulfuration pathways, will NAC be an issue for them at all? Thanks. Fairie Bellehttps://www.blogger.com/profile/02774758021444691191noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-1854378343530413052014-05-25T14:37:49.046-04:002014-05-25T14:37:49.046-04:00Do you know a good place to purchase N-acetylcyste...Do you know a good place to purchase N-acetylcysteine that you find to be a reputable source?Carolyn Bhttps://www.blogger.com/profile/06266110380514478059noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-24763717296834237332014-05-12T13:24:42.447-04:002014-05-12T13:24:42.447-04:00Hi,
I am using Nac together with alpha stim and so...Hi,<br />I am using Nac together with alpha stim and so far it is effective to cure anxiety.However taking too much seems to make you hyper;<br />Interesting article here;<br />https://www.openminds.com/market-intelligence/executive-briefings/peeesumner.htm<br />Could I mix it safely with L theanine?Anonymoushttps://www.blogger.com/profile/14881905217246628881noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19393427862045141792014-05-03T01:18:58.279-04:002014-05-03T01:18:58.279-04:00http://www.metametrix.com/files/learning-center/ar...http://www.metametrix.com/files/learning-center/articles/hypohomocysteinemia.pdf<br /><br /><br />Doesn't this suggest that taking less folic acid and B12 would lead to higher innate glutathione levels?Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-86042392496406306332014-04-30T21:57:47.137-04:002014-04-30T21:57:47.137-04:00Hi Emily,
Do you think RiboCeine by Max Internati...Hi Emily,<br /><br />Do you think RiboCeine by Max International (D-Ribose L-Cysteine), which is supposed to be more effective at boosting glutathione would also have the same NMDA antagonist properties?lawishardhttps://www.blogger.com/profile/14137621997548181153noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-42781491384788385912014-01-01T01:21:01.787-05:002014-01-01T01:21:01.787-05:00Look into ASEA. It increases glutathione 800% by i...Look into ASEA. It increases glutathione 800% by increasing the redox signalling molecules, according to research. Taken orally, it contains no drugs.Whirling Bliss Machinehttps://www.blogger.com/profile/12013785327259330769noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-34052767752440416012013-12-29T13:56:42.101-05:002013-12-29T13:56:42.101-05:00Peter, dissociatives like Ketamine induce psychosi...Peter, dissociatives like Ketamine induce psychosis for a number of reasons that extend beyond their effect on NMDA antagonism. They also block NMDA competitively, meaning that they lower NMDA below healthy levels. NMDA antagonists like Memantine and Magnesium will only lower NMDA levels that are overactive. <br /><br />Also keep in mind that dissociative type NMDA antagonists will actually raise Glutamatergic transmission. They do so through a unique pathway, but also indirectly by inhibiting NMDA so profoundly that the body in turn tries to increase Glutamate to balance it out.<br /><br />In other words, if you need a reliable NMDA antagonist that will not cause the same issues as Ketamine, then Magnesium fits the bill. eclypz - owner - alphachakra.comhttps://www.blogger.com/profile/11951501511376332983noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-61372912266045684332013-11-07T03:51:04.091-05:002013-11-07T03:51:04.091-05:00I started taking NAC as an experiment to treat my ...I started taking NAC as an experiment to treat my trichotillomania, but stopped because I suspected it was giving me stomach trouble and didn't have any noticeable improvements on my trich. Now, 8 months later, I'm still having stomach issues. I've been diagnosed with Irritable bowel syndrome (IBS) and my symptoms seem to be abnormally high sensory input from the gastric system (e.g. I feel gas, movements, nausea and other input from my stomach stronger than I should). This also includes constipation at times. Cannabis, paradoxically, also seems to potentiate these symptoms. You said that one kid in the study you mentioned got worse, and was later diagnosed with constipation. Could these things somehow be related?Ahttps://www.blogger.com/profile/03616977866493185754noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-5290852706445536592013-10-23T09:56:25.136-04:002013-10-23T09:56:25.136-04:00I am sorry to sound uneducated but what do the acr...I am sorry to sound uneducated but what do the acronyms ASEA and SOD stand for please? Anonymoushttps://www.blogger.com/profile/17564479610823813724noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-89980183843075605252013-09-16T22:51:53.727-04:002013-09-16T22:51:53.727-04:00Um you could prob find anything in SOME children w...Um you could prob find anything in SOME children with autism. This sounds more like astrology than science Drsgaronhttps://www.blogger.com/profile/00518510339676804096noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-23308840115025460442013-08-21T19:46:00.944-04:002013-08-21T19:46:00.944-04:00I'd Like to share my experience about NAC I st...I'd Like to share my experience about NAC I started taking it just as a supplement 1 tab a day after 4days of taking NAC i certainly felt the difference eye sight from 20/30 to 20/15 feeling happy and good. After 2 weeks of feeling out of this world, TINNITUS hits me like a ton of brick. I have now been suffering the worse case of ringing in my ear for 1 month and i think the soul culprit was the NAC. just sharingRockyhttps://www.blogger.com/profile/04067267911913963924noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-86304532232399825262013-08-10T01:50:15.651-04:002013-08-10T01:50:15.651-04:00Hello,Oltean Sergiu.
I can relate to your experie...Hello,Oltean Sergiu.<br /> I can relate to your experience, A panic attack is always a scary experience but one triggered by a med is the worst. I had panic attacks triggered by two anti depressants taken at the same time wellbutrin in morning & Efexxor At night.<br />I had low energy & my doctor gave me these prescriptions saying I might be depressed. I called the ambulance one night because i was weak & full of fear with tremors. I cannot even describe the terror, the horror of these panic attacks. My life took a spin. I was then put on xanax which helped. but it took almost a year for me to return to a 90% recovery. I feel it was never going to go away. I have faith in God and he helped me though it. In this time of need Jesus Christ proved to be true & real. I can say he is real not by what i read, heard or rationalized, but by the miracle he performed in my life. My body / brain was so sensitive that even supplements as simple as a Pro biotic would spin me into a horrible panic, worse if i took a calming herb like passion flower or B- vitamin complex supplement, one time I drank some aloe vera juice & panic attack! Crazy! I could not understand it. Anything with nutritional value affected me. Weird! I could not treat it with anything natural. Your brain chemistry can really take some time to recover. I was so afraid i would get addicted to Xanax, afraid i would not recover, afraid i get sick & had to take a anti biotic (like one you took) or other med, that would put me over the edge. I developed ulcers. I then let go & left it up to God, I received comfort in prayer, reading the bible, listening & trusting in him and his promises. I would only listen to up lifting music , talk , tv. Thank God he got me through this. A year later I am 95% better and doing some public speaking, something I could never do prior. God is awesome! At times I might feel anxious at times but its part of recovery. So if your are prone to anxiety / panic attacks be careful what you take. Towards the end, the reason for my low energy was my adrenals & testosterone were low. What! My fault for not getting second opinion before I took those meds.Have patience! God is good!<br />MGhttps://www.blogger.com/profile/14597353052572505133noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-69040537477246074112013-08-05T19:37:38.745-04:002013-08-05T19:37:38.745-04:00Forgot to mention he has MTHFR and growth hormone ...Forgot to mention he has MTHFR and growth hormone deficiency as well. Have never found any other child with similar issues.Weatherby Park Home Owners Associationhttps://www.blogger.com/profile/03142949427571899787noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-67832306104484761452013-07-29T22:14:50.450-04:002013-07-29T22:14:50.450-04:00My son (now 8) has been on NAC for over a year (60...My son (now 8) has been on NAC for over a year (600mg 3x a day). He has ADHD and Aspergers. NAC has been a life-saver. He used to have uncontrollable rages lasting hours every day that made him so sad because he couldn't help it. Therapies did not help. Homeopathic medicines didn't work. Omegas didn't help. Then we went to prescription medications...trying 6 different ones over the coarse of two years. Some would work but only for a short bit and they all had side effects. Then I did a bunch of research and decided to try NAC. After 3 days he stopped having rages. He still has occasional tantrums but they last a few minutes not hours. He still sees a psychiatrist who agrees it has helped immensely. The only other medication he is on is a low dose of clonidine for hyperactivity.Weatherby Park Home Owners Associationhttps://www.blogger.com/profile/03142949427571899787noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-14128191961074586572013-05-20T14:24:08.809-04:002013-05-20T14:24:08.809-04:00I took 15 days of Levofloxacine, from an antibioti...I took 15 days of Levofloxacine, from an antibiotic group called fluoroquinolones, 500mg(one pill per day) for an infection.I was already taking a benzodiazepine called Clonazepam(0.25mg per day) for anxiety and 0.25mg was working just perfect.<br />When i started taking Levofloxacine i felt very very anxious,couldnt sleep, had EXTREME panic attacks like 2-3 times a day and i had increased my Clonazepam dose 4 time to 1mg per day(and the benefits from 1mg now are weaker than they were on 0.25 mg prior taking Levofloxacine).<br />Its been one month since i took the last pill of Levofloxacine and i feel the same.I had to call the ambulance 3 times.Im acting very strange, im very afraid, im staying in my car almost all day and feel so psychotic.I never felt this way in my life. I read this is due to Levofloxacine binding to GABA/A receptors in the brain but is this going to go away? It's already been a month...<br /><br /><br />Wikipedia:<br />Fluoroquinolone antibiotics have been noted by Ashton and confirmed elsewhere as increasing the incidence of a serious CNS toxicity from 1 to 4% in the general population, for benzodiazepine-dependent population or in those undergoing withdrawal from them. This is probably the result of their GABA antagonistic effects as they have been found to competitively displace benzodiazepines from benzodiazepine receptor sites. This antagonism can precipitate acute withdrawal symptoms, that can persist for weeks or months before subsiding. The symptoms include depression, anxiety, psychosis, paranoia, severe insomnia, parathesia, tinnitus, hypersensitivity to light and sound, tremors, status epilepticus, suicidal thoughts and suicide attempt. Fluoroquinolone antibiotics should be contraindicated in patients who are dependent on or in benzodiazepine withdrawal. NSAIDs have some mild GABA antagonistic properties and animal research indicate that some may even displace benzodiazepines from their binding site. However, NSAIDs taken in combination with fluoroquinolones cause a very significant increase in GABA antagonism, GABA toxicity, seizures, and other severe adverse effects.<br /><br />Will this GABA antagonism go away so i can be back on my normal klonopin dosage?Anonymoushttps://www.blogger.com/profile/09029569181166530905noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-55919260555117640802013-03-16T01:29:28.317-04:002013-03-16T01:29:28.317-04:00Very interesting information about NAC.
ASEA has...Very interesting information about NAC. <br /><br />ASEA has been shown to increase blood levels of glutathione 800% and SOD 500%. ASEA also increases catalase.<br /><br />It provides redox signaling molecules of stabilized sodium and stabilized chloride - something that was thought to be impossible.<br /><br />I take NAC as well as ASEA since the NAC might make the glutathione last even longer.<br /><br /> Anonymoushttps://www.blogger.com/profile/04203564832948721991noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-88337504527419631532013-03-16T00:52:32.537-04:002013-03-16T00:52:32.537-04:00Emily,
Your account of people suffering from psyc...Emily,<br /><br />Your account of people suffering from psychosis as a result of an NMDA antagonist really disturbs me. I believe I would benefit from lowering my glutamate, but after reading about the "dissociative anesthetic Ketamine" (which I guess is an NMDA antagonist) and now even these other prescribes NMDA antagonists, it makes me nervous to supplement with Magnesium for my OCD. <br /><br />My fear is based on the fact that I have had a few circumstances in my life, once smoking weed, and another time after taking a caffeine pill where I felt I was pretty close to psychotic. I had panic attacks during those times, but it felt like more than that as well. As you can tell I fear losing my sanity from taking the wrong thing. My question is, is it the NMDA antagonist property that causes this psychosis? Is there reason to worry about all NMDA antagonists as they all may have this "dissociative" property about them (even magnesium in high doses)? Why is it that Schizophrenics could benefit from glutamate inhibition yet suffer psychosis from the NMDA inhibition (from ketamine, or Memantine apparently as well) that allows the inhibition?<br />Please fill me in if you know anything about this! Your post completely turned me away from Memantine as I feel I am a sensitive individual and need a 100 percent garuntee that I won't have problems with what I take. Anonymoushttps://www.blogger.com/profile/01143680112969873999noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-54763206822172164362012-08-01T02:59:23.418-04:002012-08-01T02:59:23.418-04:00I am interested in trying my son on some NAC but I...I am interested in trying my son on some NAC but I got lost when you talked about something tasting like sulpher, and overdosing on NAC or was it Tylenol. Bottom line is there Sulfer in NAC? Does Magnesium Citrate work or is there another type of magnesium you recommend? What can you tell me about NADH? Thank you your help.Anonymoushttps://www.blogger.com/profile/03667092091644055461noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-56402822521405042912012-06-23T05:56:49.068-04:002012-06-23T05:56:49.068-04:00Nice article. Emily- any advice on dosage, timing...Nice article. Emily- any advice on dosage, timing in the day, with food?Greg Davishttps://www.blogger.com/profile/09428081816773345899noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-41950268592161789192012-06-14T21:28:04.649-04:002012-06-14T21:28:04.649-04:00That said, I can't find any reference to MN in...That said, I can't find any reference to MN in GAD online. B6 yes. So maybe the older reference was wrong, or the MN requirement came from glutamate.<br /><br />Only this:<br />http://www.moyak.com/papers/manganese-enzyme-mineral.html<br /><br />Manganese is a cofactor for enzymes involved in hydrolysis, phosphorylation, decarboxylation, and transamination. It also promotes activities of transferases such as glycosyltransferase, and of glutamine synthetase and superoxide dismutase. Manganese helps in the production of enzymes used for metabolism of proteins and fat. It supports the immune system, blood sugar balance and is involved in the production of cellular energy, reproduction and bone growth.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-68938725013319112252012-06-14T21:11:55.623-04:002012-06-14T21:11:55.623-04:00http://www.ncbi.nlm.nih.gov/pmc/articles/PMC195033...http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950338/<br />This says GAD is not activated at low levels of Mn.<br />Mn for GAD I remember from an old textbook; but Mn is required for glutamate synthesis and GABA degredation as well, so is equal-opportunity.<br /><br />Thiamine might be important for glutamate as well - I think this is how Korsakoff's syndrome works (and alcoholic anmesia?) <br /><br />"Such decreases in KGDH (ketoglutare dehydrogenase) may explain previous findings of region-selective changes in energy metabolism and of decreased synthesis of glucose-derived neurotransmitters (acetylcholine, GABA, glutamate) in pyrithiamine-treated rat brain. "<br />http://www.springerlink.com/content/m112756033343422/<br /><br />Now, these are all Mn-dependent neurotransmitters; so is thiamine deficiency also a factor in manganese toxicity and/or deficiency?<br />Glutamate and GABA are glucose-derivedPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-39568851018584611672012-06-14T16:01:04.526-04:002012-06-14T16:01:04.526-04:00Astaxanthin might help with glutamate induced exci...Astaxanthin might help with glutamate induced excitotoxicity too (PMID 20828541).Stephen Boulethttps://www.blogger.com/profile/04170061924588693181noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-80349560141424006792012-06-13T11:31:57.143-04:002012-06-13T11:31:57.143-04:00Emily, do you not know about the MTHFR as it relat...Emily, do you not know about the MTHFR as it relates to GSH and Austism? And all other methylation issues? I am finding out that I have 2 copies of MTHFR A1298C, so I started NAC..but then I found out I have CBS, which is causing trouble at the top end of the methylation pathway in the sulfuric pathway...meaning I have to avoid sulfur supps and foods for awhile to clear that first before addressing the MTHFR...I'm surprised you didn't mention this? Many autistics have these issues too.Anonymoushttps://www.blogger.com/profile/17744935200161130478noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-22063859067107230072012-06-12T14:13:22.833-04:002012-06-12T14:13:22.833-04:00http://www.ncbi.nlm.nih.gov/pubmed/18466343
*Ketog...http://www.ncbi.nlm.nih.gov/pubmed/18466343<br />*Ketogenic diet increases mitochondrial glutathioneJohnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.com