tag:blogger.com,1999:blog-3045634714760830992.post6646657956490606605..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: What is Evolutionary Psychiatry?Anonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger17125tag:blogger.com,1999:blog-3045634714760830992.post-81906458784659139042012-11-19T10:49:03.311-05:002012-11-19T10:49:03.311-05:00I've heard it is a good book, though a little ...I've heard it is a good book, though a little sensationalist.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-84652664203047359882012-11-13T19:28:33.462-05:002012-11-13T19:28:33.462-05:00Oops, that first line of my post came out sounding...Oops, that first line of my post came out sounding flippant and I didn't mean that at all. I just wanted to ask what you thought about smelling the soil.<br /><br />I love your blog.Pleistocene Mindhttps://www.blogger.com/profile/08511845935977777528noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-17222423961474658352012-11-11T14:57:22.881-05:002012-11-11T14:57:22.881-05:00Would you recommend An Epidemic of Absence as a so...Would you recommend An Epidemic of Absence as a solid text?<br /><br />thanks,henrydrnhttps://www.blogger.com/profile/11075044929700530159noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-7970864180021665132012-11-09T00:08:37.435-05:002012-11-09T00:08:37.435-05:00http://www.ncbi.nlm.nih.gov/pubmed/22500660
Dietar...http://www.ncbi.nlm.nih.gov/pubmed/22500660<br />Dietary selenium and major depression: a nested case-control study.<br />After adjusting for age and SES, compared with a high selenium intake, a low intake (<8.9 μg/MJ/day) was associated with an approximate trebling of the likelihood for developing de novo MDD; OR 2.95 (95%CI 1.00-8.72). Smoking, alcohol consumption and physical activity did not confound the association.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-30907980409624653502012-11-07T14:11:37.878-05:002012-11-07T14:11:37.878-05:00I understand your advice not to go out and drink d...I understand your advice not to go out and drink dirty water, obviously, but how about smelling forest soil for help with depression? I don't think those mycobacteria are associated with human disease, right? (I do understand that other species cause TB).<br /><br />I teach nature and gardening classes to kids, and I often wonder if one of the many positive effects of outdoor play might be the smell of the soil.<br />I enjoy the smell of soil myself and wonder if it has positive effects. It could also be that the smell is connected in my mind with pleasant memories.Pleistocene Mindhttps://www.blogger.com/profile/08511845935977777528noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-4397716482050367342012-11-01T16:47:33.561-04:002012-11-01T16:47:33.561-04:00Hi Dr. Davies,
Honestly the best evidence is for ...Hi Dr. Davies,<br /><br />Honestly the best evidence is for ADHD. Lovely crossover INCA trial and then the Southampton studies… I covered them (and linked the studies) here: <br /><br />http://www.psychologytoday.com/blog/evolutionary-psychiatry/201106/how-does-diet-affect-symptoms-adhd<br /><br />And also there was a decent review later on I linked here:<br /><br />http://evolutionarypsychiatry.blogspot.com/2012/01/diet-and-adhd-literature-review.html<br /><br />And the other really nice avenues of research have been the diet and violence studies:<br /><br />http://www.psychologytoday.com/blog/evolutionary-psychiatry/201105/diet-and-violence<br /><br />And finally, the avenue that has been poorly researched but has so much potential is fructose malabsorption: <br /><br />http://www.psychologytoday.com/blog/evolutionary-psychiatry/201105/could-soda-and-sugar-be-causing-your-depression<br /><br />http://www.psychologytoday.com/blog/evolutionary-psychiatry/201204/soda-begets-zombies<br /><br />Hope that helps!!Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-31525505002938887072012-11-01T16:42:16.189-04:002012-11-01T16:42:16.189-04:00I deleted this comment by accident while trying to...I deleted this comment by accident while trying to accept it (sorry!)<br /><br />Theresa Davies has left a new comment on your post "What is Evolutionary Psychiatry?": <br /><br />Hi Dr Deans, I am a core trainee in Psychiatry in the UK in my second year (of 6). I was so excited to find your blog as I have been trying to motivate my collegues to think of dietary factors when diagnosing patients (without much success!!). I have to do a journal club presentation and I wondered if you had a randomized controlled trial I could present to get them thinking? Thanks for your help, Dr Theresa Davies <br /><br />Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19770278832439021942012-10-29T11:36:59.397-04:002012-10-29T11:36:59.397-04:00Fascinating. Funny, I had an itch to hear that exa...Fascinating. Funny, I had an itch to hear that exact Dead Weather song last night, too!Ryanhttps://www.blogger.com/profile/09079562313639682549noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-25825769345379584762012-10-28T22:00:27.637-04:002012-10-28T22:00:27.637-04:00How about adrenals and cortisol?
I've just be...How about adrenals and cortisol?<br /><br />I've just been bitchslapped back to the living with 5mg prednisone. Pain relief when absolutely nothing else worked. (Will reduce dose to see if less works.) All I can say is 'Wow!'Gabriella Kadarhttps://www.blogger.com/profile/18294468426599703416noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-55495692967637864162012-10-28T16:06:50.307-04:002012-10-28T16:06:50.307-04:00Yes, in general experiments such as deworming preg...Yes, in general experiments such as deworming pregnant mothers etc. have resulted in increased allergies and excema in the children, but sometimes exposure to worms have increased the allergic response. The subtleties are currently beyond us. And of course 50,000 kids a year die in Africa from hookworms, there are advantages to hygiene! It's all about the details, which we are only beginning to figure out.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-12073686980441585482012-10-28T15:47:05.604-04:002012-10-28T15:47:05.604-04:00It looks like timing is critical if microbiota are...It looks like timing is critical if microbiota are to prevent allergic/autoimmune disease; adding them later, not so reliable (probiotics have increased asthma in children in one trial). <br />It seems to me the inverse of the diet conundrum; VLC diets mitigate DM2 but not so easy to prove that high-carb diet causes it;<br />absence of microbiota leads to autoimmunity but not easy to prove that replacement will cure it (yet).<br /><br />It is possible to supply TLR-active PAMPs without living organisms. I am thinking a broad-spectrum approach across all the TLRs; extracts of representative species of all relevant organisms, including insects.<br />One day we might dose our kids with extracts from pinworm, fleas and headlice.<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-3848190334255804492012-10-28T14:43:05.962-04:002012-10-28T14:43:05.962-04:00thanks!thanks!Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-8476672196003075632012-10-28T10:05:15.873-04:002012-10-28T10:05:15.873-04:00There's a whole chapter in the Rook textbook a...There's a whole chapter in the Rook textbook about skin commensals, NO, and how bathing and shaving, etc. could reduce the amount of nitrates we get. My family has a farm in North Carolina where we drink spring water, obtained from a protected area so the cows don't mess with it… saprophytes, mycobacteria, eukariotic organism (like the helminths) all have a huge impact. The research is really just beginning, but it would be nice to be able to add back that piece of our immune system we are missing in a safe and effective way. Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-4685206003118670062012-10-28T10:01:50.603-04:002012-10-28T10:01:50.603-04:00Yeah, that's pretty much my take, though I'...Yeah, that's pretty much my take, though I'm not willing to say it is the only cause of depression or serotonin depletion… stress on it's own could probably do it. Certain hormones, etc. Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-23332056054100765392012-10-28T03:18:03.901-04:002012-10-28T03:18:03.901-04:00Nicotinamide inhibits IDO (because a purpose of ID...Nicotinamide inhibits IDO (because a purpose of IDO is to supply NAD+ for some reason, sirtuins maybe, respiratory burst, or to sequester it from pathogens - like iron - or all 3 plus adaptive depression).<br /><br />Reading "An Epidemic of Absence" was an illumination - I've looked at this stuff for ages in a narrow way (commensals and inflammation) but the possibilities are staggering.<br /><br />I have a well in my back yard fed from mountain streams; no human or livestock contamination, but plenty of saprophytes and algae. I've drunk from it off and on for years, but I decided to drink 2x a day or more every day and avoid bottled or tap water and pay attention to see if it helped my hay fever. <br /><br />In a word, yes, it seems to work; I've sneezed 5 or 6 times in 3 weeks; no uncontrolled fits, very little irritation of nose or eyes. We'll see if it lasts, but if it does, that will be amazing.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-4409434251421999672012-10-27T22:51:41.199-04:002012-10-27T22:51:41.199-04:00Great!!
Do you think this is more or less corre...Great!! <br /><br />Do you think this is more or less correct? Dysbiosis causes inflammation in the gut which activates IDO. IDO will stimulate the production of kynurenine which implies less serotonin and tryptophan and more 3-OH-KYN (which damages neurons) and quinolinic acid (an excitotoxin).Gonçalohttps://www.blogger.com/profile/16727714571321471043noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-7395437886717465612012-10-27T19:21:04.379-04:002012-10-27T19:21:04.379-04:00Keep it up, Emily! I love you so very much!Keep it up, Emily! I love you so very much!baileyhttps://www.blogger.com/profile/13065281512125846791noreply@blogger.com