tag:blogger.com,1999:blog-3045634714760830992.post6547059324108710628..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Omega 3s, Mice, and Receptors for Funny CigarettesAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger22125tag:blogger.com,1999:blog-3045634714760830992.post-35344539460834896822011-05-07T12:49:08.486-04:002011-05-07T12:49:08.486-04:00WIN is the profile of developmental chemicals from...WIN is the profile of developmental chemicals from Winthrop Grumann, not a particular agonist<br /><br />There are a number of cannabinoid agonists from Winthrop, and many other researchers, in fact you could buy many of them online for the past few years until the DEA recently took action...Chief Snuffhttps://www.blogger.com/profile/04186908780376698182noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-17539905813697658842011-04-25T11:27:22.421-04:002011-04-25T11:27:22.421-04:00Not sure where they fall on the n-6 scale, but if ...Not sure where they fall on the n-6 scale, but if you want a crunchy munchie that's healthier than bugles, I recommend Kale Chips. A Google search will turn up plenty of recipes. (I make mine with my Pizzazz Pizza cooker, takes about 5 min.)Kathyhttps://www.blogger.com/profile/13452494800711038540noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-68912976095890198922011-04-22T19:08:49.403-04:002011-04-22T19:08:49.403-04:00According to Yahoo answers, Bugles is made from th...According to Yahoo answers, Bugles is made from the following<br /><br />"Ingredients: Degermed Yellow Corn Meal, Coconut Oil, Sugar, Salt, Baking Soda, Nonfat Milk, Wheat Flour. Freshness preserved by BHT.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-86038482643181181622011-04-22T11:38:28.900-04:002011-04-22T11:38:28.900-04:00Jim - I'm all for mice gorging on bugles rathe...Jim - I'm all for mice gorging on bugles rather than twinkies if palm oil, salt, and corn are the primary ingredients. In fact, I might seek them out as a candy cigarette sort of snack myself… thanks for the heads up :-)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-67573410595474625162011-04-22T08:23:53.920-04:002011-04-22T08:23:53.920-04:00Dude, I've searched long and hard for a crunch...Dude, I've searched long and hard for a crunchy, salty munchie that is relatively low in n-6, so I like reeely don't appreciate the reference to bugles. They're just corn (no gliadins), salt, and palm oil. <br /><br />Have come to love your blog.Jim Suttonhttps://www.blogger.com/profile/10885310290484161911noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-47495473335395830892011-04-20T08:58:22.234-04:002011-04-20T08:58:22.234-04:00Hi blogblog - I've never done any mouse resear...Hi blogblog - I've never done any mouse research myself, but my understanding is these standard tests are used as objective measures - mice are videotaped and literally the amount of time they spend in the center is catalogued, or how long it takes them to start exploring, etc. There are several variations - and mice in certain stress paradigms (after restraint, for example, or being confined with an aggressive mouse) exhibit more anxious and nervous behaviors and are less likely to go to the center of the room, and are less likely to explore a maze, things like that. They will also tend to have different postures and scratch more, depending on the species. Whether or not this is a good model for anxiety is certainly up for debate - though it would fit with the human stress diathesis model of depression and anxiety. There are obviously levels of confidence - a mouse who won't explore might not find the cheese. A mouse who will stick his neck out too much will get its head lopped off.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-32650925136487070102011-04-20T08:39:38.109-04:002011-04-20T08:39:38.109-04:00Avoiding open spaces and staying close to walls is...Avoiding open spaces and staying close to walls is a completely normal mouse behavior that greatly reduces the risk of death. It is definitely not a sign of "depression". Wild mice are extremely cautious and exceptionally timid. <br /><br />An anxious mouse gets to reproduce.<br /><br />A confident mouse is a dead mouse.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-83844560416822210242011-04-19T18:39:27.926-04:002011-04-19T18:39:27.926-04:00Tony, 2-AG is the major EC in the brain and both 2...Tony, 2-AG is the major EC in the brain and both 2-AG and anandamide are derived from arachidonic acid (derived obviously from LA) There are a million other ECs and I'm not sure their metabolic pathways. The researchers were looking for a difference in those two levels in the paper between the mouse groups and didn't find any - but other researchers did find different levels among groups without the lifelong depletion of these mice, apparently. ECs act locally so you need a constant supply. I don't know if it drives addiction but it certainly could be possible.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-92198295541254228382011-04-19T18:03:05.172-04:002011-04-19T18:03:05.172-04:00If I am correct, then endocannabinoids anandamide ...If I am correct, then endocannabinoids anandamide and 2-arachidonoylglyceral are both derived from Omega-6 fatty acids (check the metabolism pathways). I'll be damned if there aren't endocannabinoids derived from omega-3 fatty acids. And I'll be damned if both n-3 and n-6 compete for the same enzymes. Just like the inflammatory series-2 (omega-6) prostaglandins and the less-inflammantory series-3 (omega-3) prostaglandins. Now, if too much omega-6 and too little omega-3 can drive inflammation, can it drive addiction too? By simply clogging the metabolism pathways?<br /><br />Tony Machyoutube.comhttps://www.blogger.com/profile/05888589753237168387noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-37589144267318283032011-04-19T14:35:01.996-04:002011-04-19T14:35:01.996-04:00Frank - that I cannot explain! I do like whole mi...Frank - that I cannot explain! I do like whole milk in my scrambled eggs, and my kids sure drink a lot of it, but I haven't changed anything with my blog...Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-30536453772536895842011-04-19T14:16:43.135-04:002011-04-19T14:16:43.135-04:00Hi Dr. Deans,
This is off-topic, but I noticed th...Hi Dr. Deans,<br /><br />This is off-topic, but I noticed the title of your blog in my RSS reader now reads "Drink Milk" instead of "Evolutionary Psychology". I have nothing against milk (but I prefer real cream), but it does seem strange to me!Frank Haganhttps://www.blogger.com/profile/15198118305571191898noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-50836583917737061462011-04-19T10:22:01.690-04:002011-04-19T10:22:01.690-04:00Aaron - now that I think on it, we often used the ...Aaron - now that I think on it, we often used the term "extinguished" rather than extinction, so I'm probably the one who is being imprecise. Maybe I'll change it. Hmm.<br /><br />H - no prob! Sounds like a yummy breakfast.<br /><br />Production - just because you didn't like physics doesn't mean biochem is hard to understand ;-)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-54221983572844613242011-04-19T10:19:48.600-04:002011-04-19T10:19:48.600-04:00Olddude - In a large Finnish epidemiological study...Olddude - In a large Finnish epidemiological study, women who eat more fish had less depression. In a hot-off-the-presses Nurses Health (epidemiological) study, fish intake had no relation to depression, but an increase in ALA did decrease depression (riddle me that one, Denise Minger!) Some O3 supplement randomized controlled trials showed little to no benefit for depression - the largest one to date, from Canada last year, showed an effect in depression without complicating anxiety equal to an antidepressant. No one has done a randomized controlled trial of wild caught salmon for depression, however :)<br /><br />I tend to err on the side of 1) common sense, 2) biologic plausibility, and 3) real food and 4) with a dash of "do no harm." Therefore, I do recommend (wild caught) salmon for everyone - and I can't really see why it wouldn't stack the deck a bit in your favor if you have tendencies toward depression. There are so many variables that just adjusting the omega 3 might not make an overall difference, I'm fully ready to admit.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-15787557398310509242011-04-19T09:13:29.361-04:002011-04-19T09:13:29.361-04:00Dr. Deans, thank you very much for the explanation...Dr. Deans, thank you very much for the explanation. I appreciate your help.<br /><br />Here's hoping that making the best choices we can will do more for us than improving a mouse's diet would for the mouse. Being able to make choices is the grandest thing.<br /><br />Wild salmon, pastured butter and coconut oil for breakfast this morning. :) And, Assam tea.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-47368535693083646702011-04-19T08:40:03.555-04:002011-04-19T08:40:03.555-04:00So,if I understand this post,"baked salmon&qu...So,if I understand this post,"baked salmon",could be looked at as a potential treatment for lethargy and depression?<br />Rodolddudehttps://www.blogger.com/profile/01824407764097934416noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-8592595270528164862011-04-18T21:09:21.063-04:002011-04-18T21:09:21.063-04:00Hi H. Thanks for all your nice comments! The lack...Hi H. Thanks for all your nice comments! The lack of DHA seems to screw up the g protein coupling in the cannabis receptor complex - I'm guessing this is something that should be reversed with repletion, but the long term consequences of brain development lacking major neuroplasticity systems are unknown, and that part might be irreversible.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-36121020004206618482011-04-18T20:59:16.590-04:002011-04-18T20:59:16.590-04:00Dr. Deans, thank you for another fascinating and d...Dr. Deans, thank you for another fascinating and delightful post.<br /><br />If the mice which had had the lifelong Omega-3 deficiency were put on a mouse version of an evolutionary diet, and given the best possible Omega-3 for mice, would the brittleness and shorted-out receptors be healed?<br /><br />I'm with Stabby, this post is motivation for more salmon for breakfast, sardines for lunch, cod liver oil at bedtime, etc.<br /><br />Thank you for making learning so enjoyable.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-85738772524220755422011-04-18T20:13:38.665-04:002011-04-18T20:13:38.665-04:00Hi Aaron - I'm sure you are right, though exti...Hi Aaron - I'm sure you are right, though extinction of the reflex is the term we used in neurology - they were likely being imprecise.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-63423753679761999372011-04-18T20:00:09.334-04:002011-04-18T20:00:09.334-04:00Another important paper for my files. And thanks f...Another important paper for my files. And thanks for translating all of the goobldygook terminology. The only correction I have is that the effect you called "extinction" seems more like habituation to me. Habituation is the waning of an unconditioned reflex (e.g., blinking to a looming stimulus) over repeated presentations, whereas extinction is the waning of a conditioned reflex (i.e., a Pavlovian CR) over repeated presentations.Aaron Blaisdellhttps://www.blogger.com/profile/17204484453346358921noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-17372437116165445552011-04-18T18:10:21.455-04:002011-04-18T18:10:21.455-04:00Never has reading about stuff I have no hope of ev...Never has reading about stuff I have no hope of ever understanding been so fun. WIN!Unknownhttps://www.blogger.com/profile/12222681570912597224noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-17770765415657660332011-04-18T17:52:35.574-04:002011-04-18T17:52:35.574-04:00I used to have somewhat of a funny cigarette habit...I used to have somewhat of a funny cigarette habit but since learning about PUFAs and getting enough omega 3s I haven't felt like doing any of that, or other addictive things for that matter.<br /><br />Paleo party! BYOF (bring your own fish)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-42557094810868112652011-04-18T17:24:16.760-04:002011-04-18T17:24:16.760-04:00I literally laughed out loud a couple times while ...I literally laughed out loud a couple times while reading this- thanks for a great post!<br /><br />If I were going to stick with this whole research thing, I'd love to do a postdoc somewhere with an O3:O6 model and go play with rat livers from such a paradigm... That, or I'd like to be the person that gets to name newly synthesized agonists... WIN!vlprincehttps://www.blogger.com/profile/17599039244716203792noreply@blogger.com