tag:blogger.com,1999:blog-3045634714760830992.post629135129517439629..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Medicine Is Still an ArtAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-3045634714760830992.post-26887797759613753822012-02-11T16:43:16.191-05:002012-02-11T16:43:16.191-05:00I was just reading the new insights to grehlin and...I was just reading the new insights to grehlin and the hypothalmic ovarian brain gut axis. I have a feeling that it explains the bipolar one sequence. What kind of doctor would explore the grehlin effect on the growth hormones/vagus nerve and treat that way? I realize lithium is nearly impossible to get off of, but if all the right things were measured and corrected, along with sleep and good health, it might be possible. It sure seems worth exploring.Leehttps://www.blogger.com/profile/12347686450254088830noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-23466946369763250752012-02-08T11:14:59.453-05:002012-02-08T11:14:59.453-05:00Thanks for opening that up to me. I really appreci...Thanks for opening that up to me. I really appreciate the discussion.Kieranhttps://www.blogger.com/profile/01806059777770099752noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-59176766476897968632012-02-05T14:44:07.915-05:002012-02-05T14:44:07.915-05:00@P Flooers
I hope you appreciate that none of wha...@P Flooers<br /><br />I hope you appreciate that none of what I have written is particularly controversial or outside the bounds of normal conversation and debate in discussing these recommendations. Both the editorials I mentioned were published in hugely mainstream journals. Somehow the consensus guidelines have become the voice of the fringe.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-1387618928757596352012-02-05T14:35:01.823-05:002012-02-05T14:35:01.823-05:00Effective, perhaps, but ewww... I'd rather tak...Effective, perhaps, but ewww... I'd rather take the naltrexone.strakehttps://www.blogger.com/profile/15253066549264629665noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-89964331974370132742012-02-02T11:09:53.660-05:002012-02-02T11:09:53.660-05:00@Js
"Wonder if helminthic therapy would be s...@Js<br /><br />"Wonder if helminthic therapy would be safer and just as effective..."<br /><br />The remission rates for Crohns in the penn LDN trial and in Weinstocks TSO trial at Iowa were fairly similar and both seemed to be very effective for that disease. It is very impressive that the penn trial documented remission with endoscopy as well as by symptoms.<br /><br />TSO is very expensive - requiring the maintenance of live pigs for harvesting and counting the ova to give to the patients. Since TS is not a human pathogen, it must be taken regularly. TSO treatment commonly causes GI side effects, and essentially induces a mild eosinophilic enteritis of the colon. Hookworm infection is not FDA approved and this definitely causes an enteritis which can also be symptomatic. FInally, infection with TT, or human whipworm, apparently can actually make allergies WORSE before they get better, when given for IBD.<br /><br />The bottom line is that it is remarkable how similar the efficacy is between LDN and TSO treatment for Crohn's and the putative mechanism of LDN may induce similar cytokine and cellular regulatory responses to worm infection or pseudo-infection with TSO.<br /><br />Yet LDN seems to have much fewer side effects, is easily obtainable off label, and can be as cheap as $6 a month to take if you do your own home compounding. LDN also has some theoretical side effects that could be highly beneficial, like suppression of proliferation of cancer cells.<br /><br />I don't think LDN will cure everything and anything, but its use as an immune modulator for any disease that seems to be related to failure to suppress Th1 or TH2 responses deserves to be considered further.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-42780908718620850512012-02-02T01:34:14.590-05:002012-02-02T01:34:14.590-05:00I wonder if y'all can fully appreciate how hea...I wonder if y'all can fully appreciate how healing it is for us lay folk to hear MDs admitting to a systemic problem within institutional medicine.<br /><br />THANK YOUP Flooershttps://www.blogger.com/profile/01110072444592565448noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-90113445534977800312012-02-01T19:20:40.282-05:002012-02-01T19:20:40.282-05:00Dan, you should have a blog, man. From the front l...Dan, you should have a blog, man. From the front lines. And yes, what are we doing? I spend a lot of my time cleaning up huge piles of stinking mess created by very well-meaning people (and sometimes those messes are my own!). This very morning, young person came in on 5 different meds, three of which could interact and cause a deadly heart rhythm (unlikely but certainly possible), another three of which could interact and cause seizures (also unlikely but possible.) It is awfully easy to have 20/20 hindsight but, seriously…<br /><br />Woo: to be fair I think we need to add in ignorance, stupidity, and good intentions.<br /><br />Js290: Helminthic therapy is much more expensive. Everything I've seen and heard about it would make me suspect it could be extremely effective.<br /><br />Thackray: As a psychiatrist I am already somewhat marginalized and I'm allowed (perhaps even expected) to be a bit of a kook. We are managed to some extent but not so much as the primary care doctors, who are more and more getting graded and even paid by how closely they adhere to evidenced based guidelines (having diabetics and other high risk folks on certain meds, following up with certain frequency, etc.,). But I am unclear of the future. I'm hopeful these critical editorials from JAMA and JACC mean that caution about these prescriptions is swinging back into vogue.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-84869444931980093362012-02-01T08:38:51.112-05:002012-02-01T08:38:51.112-05:00Dan’s comments above are most telling. Unless you...Dan’s comments above are most telling. Unless you are on the drug side of medicine who would want to enter or remain in this field once you have seen the “light” so aptly described by the many MD’s, PhD’s, VDM’s and just plain bright people who belong to this “choir”?<br /><br />Once you have seen the truth and speak about it you are immediately marginalized or seek to marginalize yourself.<br /><br />I think about young doctors. What if they have entered medicine knowing the truth or see the truth early in their career. How will they view their future in medicine? Eventually they will be expected to prescribe stains or some other drugs they know are useless and/or harmful. If governments / drug companies (they are hand in hand at this point) have their way, they will be prescribing these drugs to children.<br /><br />Perhaps the blogosphere is the agent of change here – I hope so. Otherwise....<br /><br />PhilThackrayhttps://www.blogger.com/profile/05733462601434748276noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-15581020169512854392012-02-01T00:33:21.556-05:002012-02-01T00:33:21.556-05:00re: LDN... Wonder if helminthic therapy would be s...re: LDN... Wonder if helminthic therapy would be safer and just as effective...js290https://www.blogger.com/profile/08157385596237909630noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-71995127733847543712012-01-31T23:12:35.883-05:002012-01-31T23:12:35.883-05:00These problems are clearly driven by greed. They a...These problems are clearly driven by greed. They are absolutely effects of greed and profit seeking and any other interpretation is naive, rose colored glasses or willful ignorance to truth.<br /><br />When it so happens that every stupid therapy/protocol in medicine happens to fill someone's pockets with piles and piles of gold (e.g. giving abilify to everyone/thing, but ignoring SAMe or any other supplement) you can't attribute that to medicine being an imperfect science, or an art. At that point, when we clearly see "stupid therapies" correlating 100% with "lots and lots of profits for someone/people" then we see it isn't an oversight, a mistake, but purposeful deception done for greed and greed alone.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-57657896640576722252012-01-31T22:04:11.916-05:002012-01-31T22:04:11.916-05:00well, friend. when you get right down to it and as...well, friend. when you get right down to it and ask yourself what it is we do in this profession of ours and what the actual benefit is, it can be a bit depressing. recently spent time taking care of someone who spent 4 days at home having an mi, then came in. discovering the complete failure of his ventricle he was transferred to our service (we of course being the university hospital) where we uncorked all the big tech (percutaneous ventricular assist devices, fancy vent strategies, nitric oxide, etc, etc) and of course nothing will work cuz when you have 2 dead ventricles and aren't a transplant candidate then....<br />did the same with some ecmo recently.....<br /><br />why no one ever asks, ummm. why exactly is this young person 400 pounds.<br /><br />amazing how many laugh at my dietary talks.<br /><br />had the pharmacist and residents point out several times last week that our patients (post CABG) weren't on their home doses (80mg atorvastatin) of meds. i found it necessary to point out that apparently said doses and meds didn't seem to be producing a benefit ....crickets<br /><br />am rather close to going out on my own, starting a gym/primary care clinic/training program. i'm ready to take care of people interested in taking care of themselves.<br /><br />statins for kids. christ.Danhttps://www.blogger.com/profile/08017283769321903865noreply@blogger.com