tag:blogger.com,1999:blog-3045634714760830992.post627617457109875087..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Nutrition and Alzheimer's Disease - Dangers of Insulin Resistance and Low CholesterolAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-3045634714760830992.post-32476395988675842732013-10-24T17:30:58.707-04:002013-10-24T17:30:58.707-04:00I wonder how you would explain the recent Johns Ho...I wonder how you would explain the recent Johns Hopkins meta-anaylsis described in this article:<br /><br />http://www.telegraph.co.uk/health/healthnews/10348491/Statins-may-reduce-dementia-by-a-third.htmlKefitzat Haderechhttps://www.blogger.com/profile/16782731397206151642noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-89444592323227807742011-06-20T11:17:12.385-04:002011-06-20T11:17:12.385-04:00Thanks Emily. I've been trying to learn more ...Thanks Emily. I've been trying to learn more about the dangers of statins - it seems like they're being passed around like candy these days. Your post is illuminating in that regard.<br /><br />I also want to rationally lower my own risk for CVD. My dad started with heart attacks in his 50's and then was further victimized by the low-fat medical dictum. I remember him spreading hydrogenated vegetable oil spread on his toast in the morning - brilliant medical minds thought up that one for sure.<br /><br />Ron Lavine, D.C.<br />www.yourbodyofknowledge.comRon Lavinehttps://www.blogger.com/profile/03414717404908829409noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-69439265529189963192011-06-19T16:05:30.039-04:002011-06-19T16:05:30.039-04:00Yes, it is the hemorrhagic, citations - GCBC, also...Yes, it is the hemorrhagic, citations - GCBC, also Steve Parker at Diabetic Med Diet blog did a post about it last year I think.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-27026298628748102512011-06-19T14:19:05.870-04:002011-06-19T14:19:05.870-04:00Emily, you wrote, " In Japan there is, in gen...Emily, you wrote, " In Japan there is, in general, lower cholesterol levels, and in Japanese low cholesterol is known to coincide with stroke risk." Do you have a citation for this? Sounds correct but would like to distinguish hemorraghic vs. thrombotic strokes as they have different causes/associated factors.<br />ThanksTom Garnetthttps://www.blogger.com/profile/05564496319301664839noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-89963002795279245002011-06-05T13:04:17.644-04:002011-06-05T13:04:17.644-04:00Great post! I shared it with my butter-loving hus...Great post! I shared it with my butter-loving husband, who in 1993 was the researcher who made the biochemical discovery of the link between ApoE4 and Alzheimer's Disease, www.ncbi.nlm.nih.gov/pubmed/8446617. <br /><br />At that time statins were starting to make a splash as a CVD treatment. He remembers thinking at the time, though cholesterol lowering might be beneficial for CVD (he knows otherwise now), it would also negatively impact the development of AD. <br /><br />It's great to see the research described so clearly and informatively.Annahttps://www.blogger.com/profile/17033443643442246531noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-73780325663106772011-06-03T14:28:48.082-04:002011-06-03T14:28:48.082-04:00Fascinating post. Thanks!Fascinating post. Thanks!Mrs. Edhttps://www.blogger.com/profile/02144247274657295271noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-14428009772112786282011-06-02T21:07:30.988-04:002011-06-02T21:07:30.988-04:00Mario - yes I totally owe you a thyroid post! Tha...Mario - yes I totally owe you a thyroid post! Thanks for the links - I have my thyroid textbook now too to be very on top of things.<br /><br />Stabby - I do think omega 3s are key - they have a lot to do with how the amyloid beta proteins fold in the first place… that's partly why I object to the characterization of Alzheimer's as "type III diabetes - while I do think it contributes, I don't think insulin resistance is the entire story by any means.<br />Agree about autophagy.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-16854857444308231762011-06-02T13:15:41.848-04:002011-06-02T13:15:41.848-04:00Looks like a theory coming together nicely, only a...Looks like a theory coming together nicely, only a few kinks to work out. <br /><br />More possible explanations to why Japanese diabetics might not be as affected. Joel Fuhrman once wrote an article about an old vegan dude who died of Alzheimers, and he attributed it to very low DHA levels (although it could also be low cholesterol) which were measured and were the "lowest I have ever seen" according to Fuhrman. Could DHA, which is abundant in the Japanese diet be a mitigating factor?<br /><br />Also the Japanese don't tend to be as plagued by massive amounts of linoleic acid. Too much PUFA, especially combined with a high glucose oxidative environment produces advanced lipid peroxidation endproducts, which I can imagine would greatly exacerbate things. That funny man Ray Peat says that a diet plagued by seed oil can be more glycating than sugar alone.<br /><br />Ketogenic diets definitely protect neurons and supply plenty of cholesterol, I also think that the autophagy they induce could be one more point in their favor.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-55032855128620838522011-06-02T10:41:32.588-04:002011-06-02T10:41:32.588-04:00I see that the triple number shows up here (peer-r...I see that the triple number shows up here (peer-reviewed, biochem society, 2005, reference #one if you want to delve further..), http://www.biochemsoctrans.cn/bst/033/1087/0331087.pdf<br /><br />(The basic logic as I understand it, is mostly that as the baby-boomer ages into the late 70s and early 80s the sheer number of people at those ages increases dramatically. This may be mostly an effect in the USA.)harpersnoteshttps://www.blogger.com/profile/10711246471408082849noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-22612858980289797782011-06-02T07:35:51.614-04:002011-06-02T07:35:51.614-04:00Hi Emily!
"Dementia is growing, expected to ...Hi Emily!<br /><br />"Dementia is growing, expected to triple in the next 40 years - if we don't figure it out"<br /><br />I did not undertand this assertation, don't you and Seneff have figured it out? ;-) Great article!<br /><br />Anyway, not wanting to be annoying, but you still owes us an article about the connection between thyroid and Alzheimer's! I think it's a great topic, since the growing incidence of both diseases.<br /><br />Suggested topics:<br /><br />Thyroid autoantibodies and Alzheimer's:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/1889144<br />http://www.ncbi.nlm.nih.gov/pubmed/1636181<br />http://www.ncbi.nlm.nih.gov/pubmed/19753541<br /><br />Higher thyroxine (T4 and free T4) and lower triiodothyronine (T3 and free T3) levels in Alzheimer's:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/17136019<br />http://www.ncbi.nlm.nih.gov/pubmed/17870208<br />http://www.ncbi.nlm.nih.gov/pubmed/20021390<br />http://www.ncbi.nlm.nih.gov/pubmed/17105838<br /><br />Thyroid medication use (T4 only, which increases T4 and free T4, frequently behind euthyroid levels, but often not T3 and free T3) and increased rate of progression of dementia in Alzheimer's: <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/19666883Mario Iwakurahttps://www.blogger.com/profile/15764058142849243458noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-84329032945603655842011-06-02T00:25:52.604-04:002011-06-02T00:25:52.604-04:00Its not the plaque......wrong target. Its how the...Its not the plaque......wrong target. Its how the plaque forms that is the key. And that answer lies in faulty quantum mechanical biology me thinks! Great blog! Dr Kjohnhttps://www.blogger.com/profile/11126132841611727249noreply@blogger.com