tag:blogger.com,1999:blog-3045634714760830992.post4517042969998448509..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: B12, homocysteine and Alzheimer'sAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-3045634714760830992.post-21758084485770203732015-03-01T08:20:38.017-05:002015-03-01T08:20:38.017-05:00Elevated Homocysteine is a sign of sulfate deficie...Elevated Homocysteine is a sign of sulfate deficiency. Brain Endoplasmic Reticulum low in Cholesterol Sulfate = Dementia. Lots of 85-90 year olds in my town on Epsom salt and no meds.David Bhttps://www.blogger.com/profile/11266046963020498076noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19151238663626597912011-08-31T20:45:45.087-04:002011-08-31T20:45:45.087-04:00PR - literature seems pretty consistent with respe...PR - literature seems pretty consistent with respect to MMA being positively correlated with homocysteine and inversely correlated with serum B12 - I've not checked that myself. I've had PCPs ignore my low B12s and recommend against supplementing because there were no hematologic findings, though. Very annoying.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-73307783532705646692011-08-27T17:23:41.855-04:002011-08-27T17:23:41.855-04:00What are your thoughts on the use of serum MMA to ...What are your thoughts on the use of serum MMA to detect B-12 deficiency. I almost always see MMA well WNL even with B-12 in the 200's in my patients. Also, my experience with vitamin D mirrors yoursPsych Resourcehttps://www.blogger.com/profile/18236144451935920260noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-2898643726710336302010-11-10T21:44:49.005-05:002010-11-10T21:44:49.005-05:00Paleo Rob - just reminding myself here that Mauriz...Paleo Rob - just reminding myself here that Maurizio Fava did a review of b vitamins and the different formulations in the journal of clinical psychiatry in 2009 - I'm going to look at that and get back to you (either here or in another post). <br /><br />Cathy - thanks for the support! I think the alzheimer's/infection idea is very compelling, and I do plan to do a post on it, though I have pulled papers on some other topics to cover first. Thanks for the link!Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-77909511795068559592010-11-10T20:23:23.161-05:002010-11-10T20:23:23.161-05:00Hi
This is likely the wrong specific post for this...Hi<br />This is likely the wrong specific post for this, but I'd love your thoughts on this article tying HSV1 to Alzheimer's disease: http://www.medscape.com/viewarticle/729391<br /><br />The authors tie the risk factors to ApoE4, inflammation, etc. <br /><br />As a bit a background, I feel stalker-ish but I've followed your blog(s) since you were once doing body for life, short fiction, mommy blogging, etc. I'm a PhD in biochem but also passionate about performance nutrition and wellness in general. I've personally learned through trial and error (aka elimination dieting) that casein and gluten are terrible for my body, and love what you are doing with this specific blog. Awesome stuff. Please keep it coming. <br />CatherineCathyhttps://www.blogger.com/profile/17228626311180463029noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-28554587566364693232010-11-01T16:36:36.567-04:002010-11-01T16:36:36.567-04:00Paleo Rob - I will look into that. I haven't ...Paleo Rob - I will look into that. I haven't answered it before!Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-57066302211985776702010-10-31T18:22:31.185-04:002010-10-31T18:22:31.185-04:00Emily, I would love here your take on the whole na...Emily, I would love here your take on the whole natural vs synthetic B-Vitamins debate. Thing's such as Sulbutiamine etc.<br /><br />Apologies if you have answered this before!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-80672819346364073072010-10-31T17:29:53.747-04:002010-10-31T17:29:53.747-04:00Qualia - definitely no known Prozac or wellbutrin ...Qualia - definitely no known Prozac or wellbutrin deficiencies. However, I've repleted several patients to the 50s level of vitamin D3 with only subtle results. I did it day by day with more physiologic doses, however, not 50,000 or 20,000 - more like 4k or 2k per day. I know my posts are pro antidepressant - however the basic science research seems to be quite pro- antidepressants. I'm guessing SSRIs are perfect for rats.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-20336537301012552612010-10-31T16:31:45.400-04:002010-10-31T16:31:45.400-04:00all i know (i.e have read) is that lowering homocy...all i know (i.e have read) is that lowering homocysteine with folate AND B12 doesn't change the risk for heart disease at all. so i think the question for B12 is already answered there. but it could be different with regard to the brain of course. apropos depression - did you know the following:<br />"Activated vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine and norepinephrine. Low vitamin D may contribute to chronic fatigue and depression. Seasonal Affective Disorder has been treated successfully with vitamin D. In a recent study covering 30 days of treatment comparing Vitamin D and 2 hour daily use of 'light boxes', ***depression completely resolved in the D group***, but not in the light box group."<br /><br />did you ever actually have a patient with depression walking into your practice that had an optimal (say, >=50ng) D level? meaning, could id be, that D deficiency is actually (statistically) the MAIN cause of depression? i'm asking because i just started megadosing D3 after my more conservative dosing regime (i.e. up to 10kIU) failed to raise my level over 24ng for over half a year. now, a few days ago i tried 50'000IU out of curiosity, and BOOM!! my brains suddenly wakes up and almost goes into overdrive! now, after tinkering around with different dosages, i found out that the neuro-boost effect starts at around 15kIU, is "optimal" at around 20kIU, and even feels a bit too strong from 25kIU and above. at 20kIU, it feels pretty much like 150mg wellbutrin, which i also tried out of curiosity just recently. <br />Q: have you ever tried treating a depressed patient with high(er) doses of D, like 20kIU or even 50kIU? could it be that this is actually all what is needed on the biological level, provided that all other nutritional deficiencies can be ruled out? i mean, there is certainly no known prozac or wellbutrin deficiency in humans right? but the same is not true for D! could it be that most depressed patients actually would need a few month of supra-physiological levels of D to make up for the decades of D deficiency the were walking around all the time to re-balance their neuro-transmitter levels? i mean, it seems to do exactly that with my brain (for now at least). what are your experiences with D supplementation and neurotransmitter levels?qualiahttps://www.blogger.com/profile/12612054480291962053noreply@blogger.com