tag:blogger.com,1999:blog-3045634714760830992.post3613498597599203635..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Mom's Wheat Sensitivity and Offspring's Schizophrenia RiskAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger24125tag:blogger.com,1999:blog-3045634714760830992.post-29505447792444836062012-05-16T10:22:48.604-04:002012-05-16T10:22:48.604-04:00Have a look at this from The Saccharine Disease. ...Have a look at this from The Saccharine Disease. <br /><br />"Regarding mental disease in the people of the Transkei, I can say that in the past 11 years I have not diagnosed a single case of schizophrenia in a tribal African living on an unrefined carbohydrate diet, whereas this disease is the commonest psychosis among the urbanized Africans." Letter from Dr Daynes dated September, 1971; p25Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-37631591437154917982012-05-16T09:54:31.653-04:002012-05-16T09:54:31.653-04:00'..most of us aren't rampantly vitamin and...'..most of us aren't rampantly vitamin and mineral deficient as we were in the past..' Actually we might be. According to official Recommended Daily Allowances, we aren't. But suppose they're wrong? The RDA for copper in the US was recently set at exactly the level found by Leslie Klevay to cause symptoms of heart disease in volunteers. He and many other copper researchers believe MOST OF US have copper deficiency, which is implicated as a major cause of heart disease. Without copper, iron cannot get out of cells, and iron overload is implicated as a cause of practically everything.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-57640861010867390592012-05-15T23:28:18.282-04:002012-05-15T23:28:18.282-04:00Testing for casein antibodies doesn't tell you...Testing for casein antibodies doesn't tell you whether someone is sensitive to casomorphins or other prolamines. If you're looking for antibodies to suspected food triggers, shouldn't it be the digested forms you look for, the commonly found or suspect products of partial digestion?<br />(So I would largely discount IgG testing for gliadin or casein sensitivity because it will under-diagnose amongst the wider array of possible antigens arising from these proteins. The opposite reason from you, perhaps.)<br />This finding re: gliadin might just be the tip of the iceberg.<br />Unless it is handling, not eating, wheat that causes the problem...<br /><br /><br />Another reason why lower rates of schizophrenia might be expected in the developed world is lower stress. <br />Fewer suicide bombings, genocides, drone attacks, famines and all that.<br />Also, I've known a few schizophrenics in my life and I don't recall any of them being fat (before the psych drugs).<br />In fact, if there is one psychosis trigger I would single out from my experience, it is suddenly not eating for some reason.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-53259050993575096242012-05-15T13:34:51.784-04:002012-05-15T13:34:51.784-04:00This is a little off topic, after reading the firs...This is a little off topic, after reading the first comment I wanted to share a personal observation I had recently. I've been taking Ambien for years for insomnia possible in part because I have restless leg syndrome. I recently decided to wean off the Ambien even though the only side effect I had from the Ambien was good restful sleep. I decided that I was going to supplement with some L- tryptophan and then add in some Melatonin to help me to wean off, but I also decided to try Magnesium. The first night I took the Magnesium my legs felt "quiet." My legs always feel achey, jittery, but after the Magnesium nothing and it last most of the day also. I'm down to 2.5mg of Ambien and I don't really think I need that. I'm sleeping like a baby and my feeling is that it's more the Magnesium than the melatonin or the L tryptophan.Stacyhttps://www.blogger.com/profile/02219647402071285828noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-50325507933306225342012-05-15T12:39:41.722-04:002012-05-15T12:39:41.722-04:00Hi Emily -
If inflammation is, indeed, the mecha...Hi Emily - <br /><br />If inflammation is, indeed, the mechanism of action does this raise the possibility of prophylactic administration of anti inflammatory agents during pregnancy to mitigate developmental risks? <br /><br />i.e., <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/19344884<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/21219105<br /><br />Of course, such an action with be fraught with other unknown risks, but as a society, we seem to have replaced infection with inflammation, this might be something to consider.<br /><br />- pDpassionlessDronehttps://www.blogger.com/profile/05398721312156704738noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-80455384546662904402012-05-15T09:32:25.946-04:002012-05-15T09:32:25.946-04:00We have overnutrition and seed oils and processed ...We have overnutrition and seed oils and processed grains… but most of us aren't rampantly vitamin and mineral deficient, as we have been in times past. Our health is not optimal with the modern diet, by any means. (and lest anyone be confused by my answer to another comment, I don't think wheat is a health food. I personally put it in a group with candy. It's fun to eat sometimes, it's not going to ruin your gut forever should a molecule pass your lips, but some of us are extremely sensitive or allergic to components of it and should avoid it always).Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-21621716628069346882012-05-15T09:28:57.986-04:002012-05-15T09:28:57.986-04:00Woo--I agree that the different subtypes are all l...Woo--I agree that the different subtypes are all lumped together, and we are really talking about different diseases with a similar common endpoint (thank you, DSMIV). Hebrephrenia and catatonic schizophrenia are vanishingly rare nowadays, but was a major subfraction (I think 30% were hebrephrenic, and fewer catatonic but not an insignificant amount) in the very careful descriptions by Schneider and Kraepelin and those guys, of thousands and thousands of patients. That was the late 1800s and early 1900s, the heyday of industrialization of some food and white bread without fortification.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-78769175229387639382012-05-15T03:41:22.535-04:002012-05-15T03:41:22.535-04:00If this is true wouldn't it instantly disprove...If this is true wouldn't it instantly disprove a wheat / immunological mechanism?<br /><br />Although isn't it also true "schizophrenia" is a huge disease with paranoid and disorganized and generally no similarity between subtypes other than the fact patients are all typically young, more often male, and irrational/crazy totally?<br /><br />I've heard that disorganized / catatonic schizophrenia relates more to maternal malnutrition and starvation, and prenatal infection, whereas other forms of mental illness like paranoid schizophrenia may be more related to the environments found with prosperity. If rates of schizophrenia are stable at 1% all over the world, it might be possible that these are very different types of schizophrenic patients, and totally different pathophysiologies... <br /><br />I do tend to eyebrow raise the "1% everywhere" statistic as it seems to contradict other evidence such as catatonic schizophrenia is less common in prosperity and maternal overnutrition.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-51012594105314701932012-05-14T23:52:18.656-04:002012-05-14T23:52:18.656-04:00But Emily, it seems to me that the bad diets are g...But Emily, it seems to me that the bad diets are getting worse and more widespread. Low fat nonsense is everywhere and raw milk drinking is being squashed by the FDA.Roger Birdhttps://www.blogger.com/profile/17007960782863914229noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-73036998013270438132012-05-14T23:40:16.066-04:002012-05-14T23:40:16.066-04:00I spent a few minutes reading on Dohan, and it see...I spent a few minutes reading on Dohan, and it seems reminiscent of Weston Price: a guy that comes along early, gets things right, and is overcome by the conventional wisdom, such as it is, and "paid for" science. This is not an unusual scenario, when you consider market forces and the lack of repute and low regard accorded to nutrition based causes for illness. I mean, isn't mental illness properly treated by the (lifelong) use of drugs? Don't we all know that? And another example: How well does Vitamin D work on cancer?Richardhttps://www.blogger.com/profile/13579689230767618822noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-37323059824898751492012-05-14T22:25:39.651-04:002012-05-14T22:25:39.651-04:00Perhaps the incidence of schizophrenia really is e...Perhaps the incidence of schizophrenia really is everywhere the same, except in the West, where better nutrition, antibiotics, and protective obesity are bringing it down; except in the case of wheat eaters, who don't benefit from that protection; so the rate is the same after all...<br />Wheat decides, in part, which people with schizophrenia genes will get them activated.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-79843374848111754192012-05-14T21:33:34.644-04:002012-05-14T21:33:34.644-04:00Oh, I know. Are the old friends not a philosophic...Oh, I know. Are the old friends not a philosophical representation of the whys and wherefores of evolutionary medicine?Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-16021231205102240292012-05-14T21:32:40.673-04:002012-05-14T21:32:40.673-04:00The diets of the early industrial age were pretty ...The diets of the early industrial age were pretty horrendous. How did we turn out?Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-62494424096695926242012-05-14T21:31:19.390-04:002012-05-14T21:31:19.390-04:00I think for most people without celiac (particular...I think for most people without celiac (particularly celiac, where each molecule is very dangerous), or other gluten sensitivity, gluten can be eaten in moderation without too much of an issue. Though of course I don't like grains displacing other more healthy calories, myself (and those who have the patience to prepare certain grains properly can get some real good nutrition out of them), I'm not going to begrudge most the occasional slice of pizza or birthday cake. It's not a daily indulgence for me by any means.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-21062715167316066972012-05-14T21:27:50.031-04:002012-05-14T21:27:50.031-04:00Though Dohan thought there was an increase in schi...Though Dohan thought there was an increase in schizophenia in wheat-eating regions, every big name lecturer on schizophrenia and worldwide trends I've ever seen, including some of the foremost researchers in the world, mentions the remarkable similarity in the incidence of schizophrenia (approximately 1%) everywhere.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-6981996545033532282012-05-14T21:25:36.737-04:002012-05-14T21:25:36.737-04:00The lack of association with casein makes me suspi...The lack of association with casein makes me suspicious it really is partly a gluten issue, but you're right, and I hate IgG alone partly because it doesn't tell you as much as combinations of inflammatory markers and whatnot will. But they were working from old bloodspots so what can you do?Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-46499841643872361422012-05-14T19:27:08.354-04:002012-05-14T19:27:08.354-04:00Wherefore actually means why or for what reason, n...Wherefore actually means why or for what reason, not where.Armand Cognettahttps://www.blogger.com/profile/18289426102707360199noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-80480191612688955972012-05-14T14:04:30.082-04:002012-05-14T14:04:30.082-04:00Emily, my comment is not related to this post, but...Emily, my comment is not related to this post, but I don't see how to email you. I read this article today http://www.nytimes.com/2012/05/13/magazine/can-you-call-a-9-year-old-a-psychopath.html?_r=1&smid=FB-nytimes&WT.mc_id=TM-E-FB-SM-LIN-CYC-051412-NYT-NA&WT.mc_ev=click&pagewanted=all Very sad and disturbing, and I wonder if any research has been done on the diets of these children. With my limited knowledge, I have to wonder if the epilepsy diet (90% fat) would lead to any improvements. I would love to hear your thoughts.Triciahttps://www.blogger.com/profile/00526862947309990907noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-39974843193371419732012-05-14T09:16:54.898-04:002012-05-14T09:16:54.898-04:00This whole epigenomics issue is scary in light of ...This whole epigenomics issue is scary in light of the dreadful diets people have had for the past 100 years. Are we going to have a tsunami of neurologically damaged children (special ed.) because their grandparents ate Twinkies and other garbage.Roger Birdhttps://www.blogger.com/profile/17007960782863914229noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-16760837480653016972012-05-14T03:55:33.104-04:002012-05-14T03:55:33.104-04:00IMHO it's knackered guts that's the main p...IMHO it's knackered guts that's the main problem, rather than the types of proteins that are eaten. That said, eating <b>excessive</b> amounts of slow-to-digest proteins (e.g. glutens, casein etc) is asking for trouble even in people with guts that aren't knackered.<br /><br />See <a href="http://www.direct-ms.org/pdf/LeakyGutGeneral/FreedGutImmunology.pdf" rel="nofollow"><b>Physiology and Immunology of Digestion</b></a><br /><br />Jamie has blogged quite a bit on what knackers guts, as have I.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-24021771769846301142012-05-13T22:39:22.427-04:002012-05-13T22:39:22.427-04:00This sounds like something that is simple enough t...This sounds like something that is simple enough to get a rough handle on: what are rates for schizophrenia in mainly or exclusively rice eating cultures, compared to much less rice eating cultures? Or non-grain eating cultures, if such a culture exists? Of course, not all countries or locations collect the necessary information, or do so in any helpful way.<br /><br />What is very interesting is that it does not seem to relate to gluten/celiac directly. For that matter, it may be some yet unsuspected part of the wheat protein.<br /><br />Maybe pregnant women should avoid wheat?Richardhttps://www.blogger.com/profile/13579689230767618822noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-41569250685778497962012-05-13T19:14:03.126-04:002012-05-13T19:14:03.126-04:00Jane has a point: manganese is the active-site min...Jane has a point: manganese is the active-site mineral catalyst for the peptidase enzymes that hydrolyse prolamine bonds. A deficiency of managanese (or an enzymatic polymorphism that decreases manganese utilization at low intakes) would result in gliadorphin and beta-casomorphin7 surviving in the gut. The persistence of prolamines due to incomplete digestion must surely be an early trigger for autoimmune sensitivity to them. Elevated levels of interferons seem to be another.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-90120412582009064392012-05-13T12:33:38.400-04:002012-05-13T12:33:38.400-04:00I have heard a lot of bad things about gluten and ...I have heard a lot of bad things about gluten and I believe many people have gluten sensitivity to some extent more or less. For those with full-blown celiac disease, they should not consume even a single drop of it. But for those without full-blown celiac that wants to avoid the toxic effect of gluten, can benefits be achieved by limiting gluten? Or does one need to eliminate it completely in order to see any benefits at all? Some say "all or nothing", others say there is a dose-sensitive effect.Anonymoushttps://www.blogger.com/profile/15787417321539228927noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-39785577161921760042012-05-13T08:01:13.987-04:002012-05-13T08:01:13.987-04:00One risk factor is missing from your list: minera...One risk factor is missing from your list: mineral deficiencies. This seems to be a taboo subject among brain scientists, at least here in Oxford. But sensitivity to wheat and the structural abnormalities seen in schizophrenic brains are both arguably caused by mineral deficiencies. Not of iron, zinc and calcium; we actually have too much of those. Manganese, copper and magnesium, which are antagonists of iron, zinc and calcium respectively.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.com