tag:blogger.com,1999:blog-3045634714760830992.post2761437972440019248..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: Stress and Your Gut (Or At Least A Mouse's Gut)Anonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-3045634714760830992.post-85658197437476633382011-05-16T07:23:06.328-04:002011-05-16T07:23:06.328-04:00As the paradigm of a bacteria-filled gut spreads t...As the paradigm of a bacteria-filled gut spreads through allopathic medicine, I hope we see MD's waking up to the ramifications...Ken D. Berryhttps://www.blogger.com/profile/08473299157405035193noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-16286390305154959412011-04-01T12:26:44.105-04:002011-04-01T12:26:44.105-04:00As far as I know, at the moment it is only being u...As far as I know, at the moment it is only being used in research in the US. Don't know about elsewhere. And typically it is arranged to have a transplant from a relative or partner.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-27459051867402152412011-04-01T12:22:45.876-04:002011-04-01T12:22:45.876-04:00I don't know how to arrange a fecal transplant...I don't know how to arrange a fecal transplant. Is it as effective as eating Paleo-style for at least a year? My asthma symptoms are gone , I am very happy and balanced, but eczema resurfaces from time to time, weight loss is extremely slow (I don't complain about it, just comment on it as a part of picture). Under-active thyroid due to a wrong autoimmune response also is in a picture (Armour thyroid is taken for that). Is it possible to get the same result with the long-term diet as with a fecal transplant?Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-58306854658076318532011-03-28T10:00:31.394-04:002011-03-28T10:00:31.394-04:00Hi John - what am I surprised about? I'm not ...Hi John - what am I surprised about? I'm not following the context of your comment, though the information is very interesting (and not surprising!) As Nick suggests, there is something very interesting about how everything in depression (except shock therapy) is about 55-60% effective (therapy, meds, take your pick, though the combination is perhaps more effective), placebo 40-50% effective. How much is the beastie effect? Even in the Schizophrenia and Wheat early studies it was suggested that the old neuroleptics helped repair the gut.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-30972193687215533422011-03-28T00:17:35.476-04:002011-03-28T00:17:35.476-04:00Emily I am surprised your a bit surpised about thi...Emily I am surprised your a bit surpised about this. There is even more compelling data already out there. Elizabeth Blackburn just won a Nobel Prize in medicine for work on telomeres. She also uncovered in 2009 and then again in 2010 a link between Cortisol Norepinephrine and Epinephrine in pregnant mothers who had severe stress and the effect on their telomeres. Every women stressed has documented shortening while the control group did not. A London study follow up was done to make sure there were no confounders and done with identical twins. They confirmed the finding. This clearly proves that the mind body connection is mediated by epigenetic controls. The three stress hormones have immediate and huge epigenetic effects on methylation and histone acetylation. Dr. Kjohnhttps://www.blogger.com/profile/11126132841611727249noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-62429510648065003902011-03-27T16:01:27.511-04:002011-03-27T16:01:27.511-04:00Very informative -- thanks! This makes me even mo...Very informative -- thanks! This makes me even more glad that I've taken up fermenting lately. :)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-90192729999753989912011-03-27T10:32:52.971-04:002011-03-27T10:32:52.971-04:00Wow, Emily, thank you for this incredible post. R...Wow, Emily, thank you for this incredible post. Really brings to focus the often referred to 'mind/body connection', except it seems it would be more accurate to call it the body/mind connection. One can imagine that perhaps there is an inkling of an explanation for why the placebo effect is so powerful - something is happening that may have an actual physical effect produced by the beasties interaction with our brain.Nickhttps://www.blogger.com/profile/05352151855145958818noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-74465566252577982882011-03-26T20:40:50.564-04:002011-03-26T20:40:50.564-04:00Thanks Emily.
With regard to gut bacteria and hum...Thanks Emily. <br />With regard to gut bacteria and human health, I can recommend looking at the work of Prof. Jeremy Nicholson and his group based at Imperial College, London. Prof. Nicholson and his very technologically advanced Unit at the Biomolecular Medicine Dept have looked at various conditions (somatic and psychiatric) with regards to gut bacteria. Attached is a link to an article he did for Scientific American a few years back: <br />http://www.scientificamerican.com/article.cfm?id=jeremy-nicholsons-gut-instincts<br />As for texts on gut bacteria, anything by Prof. Glenn Gibson based at Reading University, UK is highly recommended:<br />http://www.reading.ac.uk/food/about/staff/g-r-gibson.aspx<br />The fecal transplant... Make mine an enterically coated formulation rather than a naso-gastric tube and enema!Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-30673860025397789282011-03-26T19:58:55.335-04:002011-03-26T19:58:55.335-04:00So many bells went off for me when I read this, es...So many bells went off for me when I read this, especially with my own recent experiences. Thanks so much.Irenehttps://www.blogger.com/profile/03163803961338323135noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-19168920247247052912011-03-26T18:26:36.793-04:002011-03-26T18:26:36.793-04:00Fascinating article. Thanks so much for posting th...Fascinating article. Thanks so much for posting these.Susanhttps://www.blogger.com/profile/10846307115018186758noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-60776351391429581992011-03-26T18:25:35.095-04:002011-03-26T18:25:35.095-04:00Hi Paul - that is interesting - I'm going to h...Hi Paul - that is interesting - I'm going to have to look at my "Microbiology Made Ridiculously Simple" book from medical school to brush up again on the different species and their characteristics. I wonder if there is a good text about this? Seems to me that if all of the real work has been done since 2007, it would be hard to have a good text. The full text of the Bailey paper is explicit about the different species and the ones associated with the most IL-6. Very intriguing. Also, if you ever have a fecal transplant, make sure it is from a slender, non-asthmatic, happy person!Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-82791414481865675952011-03-26T16:09:48.160-04:002011-03-26T16:09:48.160-04:00An interesting post. I like this kind of study. No...An interesting post. I like this kind of study. Not the fact that some of our murine friends have gone to the big cornfield in the sky as a result I would add, but studies where behaviour/psychology is shown to potentially impact on our physical functions and being.<br />I think there are some interesting aspects to this study (reiterating your caveat focusing on mouse and extrapolating to humans) - not least mention of clostridia spp. <br />Clostridia (and other anaerobes) really has a bad reputation in relation to lots of different conditions. <br />In autism, clostridial colonisation has been frequently mentioned, e.g.:<br />http://www.ncbi.nlm.nih.gov/pubmed/15528506<br />and when some pretty strong antimicrobials are used in an attempt to erradicate such species, there is some ('some') short-term potential benefit reported:<br />http://www.ncbi.nlm.nih.gov/pubmed/10921511<br />I had always thought that the short-term nature of such an antibiotic effect was due to something like a 'homeostasis' of our gut microflora.<br />What this murine paper potentially adds to this - if extrapolated, and it is still a big 'if' - is to say that 'stress' exposure (and the reaction to that exposure) may proliferate gut bacterial populations back to anaerobic species; bearing in mind the link between autism and heightened arousal. <br />Mmm.. I am very interested.Paul Whiteleyhttps://www.blogger.com/profile/14288851488012254897noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-9323358707772925402011-03-26T15:40:41.157-04:002011-03-26T15:40:41.157-04:00Brilliant summary - we have a thread running over ...Brilliant summary - we have a thread running over at MDA about the mental health improvements many find becoming Primal (there's another one going at Art De Vany's too), this is yet another potential explanation for the phenomena and I guess for improved immunity generally amongst the Primal bunch. Primal certainly helps the wee beasties :-)Cavegirlhttps://www.blogger.com/profile/02319318255360473712noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-18896297569916368362011-03-26T15:35:34.400-04:002011-03-26T15:35:34.400-04:00Cool stuff. I've only recently discovered tha...Cool stuff. I've only recently discovered that the industrial-ag complex has known for years what the paleo/health community is just now finding out... that gut microbes affect weight. Apparently it's been known for decades in the meat industry that if you feed animals low level antibiotics they put on weight much better. Yeah- all those antibiotics people get worked up about, it's not to keep the animals 'healthy', it's to keep them sick enough to get fat!vlprincehttps://www.blogger.com/profile/17599039244716203792noreply@blogger.com