tag:blogger.com,1999:blog-3045634714760830992.post136568269756060979..comments2023-06-05T11:51:38.383-04:00Comments on Evolutionary Psychiatry: ScratchyAnonymoushttp://www.blogger.com/profile/04429177284200775781noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-3045634714760830992.post-46891267362446059432010-12-22T04:21:35.584-05:002010-12-22T04:21:35.584-05:00I noticed in the artlce above, Emily you have:
&q...I noticed in the artlce above, Emily you have:<br /><br />"I conceptualize serotonin and dopamine levels in the brains as see-saws. "<br /><br />The key word See Saw triggered a memory of something I Read a LOOOONNNG time ago, but it's always stuck out to me. It was in a rather academic resource someone had, I had just picked it up thinking, sheesh, I can't comprehend this, but seeking a challenge I recall this literal see-saw diagram that showed AcH with Dopamine DO have a see-saw relationship, to which I once thought, hey - if you decrease Dopamine ? I bet you could increase AcH - I've learned with AHD ? it doesn't work this way. I think it was Germany or Russia where that research didn't pan out.<br /><br />BUT - I went to print.google.com to see if I could find a medical textbook that had these terms to share with you that INDEED, there REALLY IS a relationship between dopamine and AcH - <br /><br />http://books.google.com/books?id=U7J4ls49HkIC&pg=PA52&dq=acetylcholine+dopamine+see+saw&hl=en&ei=17wRTbvbBYOglAei38i6BQ&sa=X&oi=book_result&ct=result&resnum=3&ved=0CDMQ6AEwAg#v=onepage&q&f=false<br /><br />It's on page 52, it may or may not come up, print.google.com is like that, I read some books by logging in with other IP's because I can't afford to buy them, but it serves up different pages usually if you do it right.<br /><br />3 weeks from now ? Some article will be out saying that's all wrong ! lol<br /><br />One thing for sure, SHARP chemistry skills I think can lead the way out of this dark tunnel. I don't have those, but I intuit having a solid grasp of chemistry - DEEP grasp is probably critical in understanding neuropsychiatry. First thing I'd do as a doctor with EVERY patient though is have a genetic screening performed to check for P450 problems, and other known genetic dispositions. <br /><br /><br />A friend of mine got his Masters in Chemistry, then ? became a pharmacist. Now, THERE is someone who will understand and even probably catch something that software might otherwise overlook. I REACH for that ? but my oh my - I find chemistry SO abstract at times, I usually have to just start accepting abstract models, abstract terms, and I try to remember, that what I may be trying to grasp in 30 minutes may have taken thousands of people researching for decades or years prior.<br /><br />The pre-requisites required to advance from all of the labors of the past are sometimes more burdening in perception I do say, than any foreseeable benefits, but it's only AFTER seeing the -kines so often or the -folates, or the tetra- or Hydro- prefixes and PLENTY of free thinking to 'conceptualize' I think do breakthroughs come about. I think intuition is the breadwinner in the end for innovation, the intellectual aspects are merely backup ! heh- just my take.<br /><br />What I was trying to say earlier is, I think there is a great synergestic relationship for the neurotransmitters more so of value than any by themselves. But molecular chemistry ULTIMATELY comes down to really understanding the atomic elements. For me - JUST figuring out what is analagous to molecular and what is the analog to atomic in regards to neurotransmitters is seemingly ? impossible ! heh.<br /><br />But again, when I see things over and over and over such as - methyl donors decrease as we age, I can't help but think, I should explore supplementing those, AND also explore finding out WHY that is, and reach for an upstream solution. Seems there is ALWAYS an upstream solution. <br /><br />One of my childhood fascinations was following streams until you couldn't tell where they came from - I sometimes feel that way in seeking to understand domains that require an expertise which I know is out of my reach, alas ! Why it's so good to communicate and learn with and from others, to teach and be taught... ALAS a BLOG such as yours Dr. Deans.Tim Miltzhttps://www.blogger.com/profile/07606036610890811747noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-53005127978860660652010-12-22T03:54:23.658-05:002010-12-22T03:54:23.658-05:00Sometimes one can seek to increase serotonic ? Bu...Sometimes one can seek to increase serotonic ? But I do say- IF the receptors are not - how shall we say ? as receptive as they COULD BE? amplifying THAT is probably a better path, or restoring that- and to that ?<br /><br />One of my favorite articles of all time - on neuronal regrowth ? <br /><br />http://genedynamics.bme.ufl.edu/Pubs/assets/Ying_ogle_07.pdf<br /><br />As well as increasing S1a at the least. Sure it's not all of them, but hey - it's a start. <br /><br />All form Curcumin - <br /><br />I was reading an article about a village in India with high curcumin intake and very low AHD.Tim Miltzhttps://www.blogger.com/profile/07606036610890811747noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-59438211275154514502010-12-22T03:31:07.209-05:002010-12-22T03:31:07.209-05:00Looks like Gustav Jung's promotion of Intuitio...Looks like Gustav Jung's promotion of Intuition over intellect is on again:<br /><br />http://www.bioportfolio.com/resources/trial/73908/Trd-2-A-Study-Of-6-s-5-mthf-Among-Selective-Serotonin.html<br /><br />Looks like Mass Gen has an ongoing study on 5MTHF. <br /><br />Gee, I only wanted it because it was a decent methyl donor, I just read such nasty business about Homecysteine, from meats and cheeses, even to Alzheimer's possibly being caused by too much Homecysteine because we supposedly progressively lack methyl donors in aging. Me? When I see ANYTHING that changes as we age? I like to start examining, is it a casual factor ? or effect of something else, or is the effect of one thing, a cause of another... Seems I may be looking at biochemistry as a hierarchy - all wrong, I'm guessing the winning game of chess each time is through a careful process involving many thought processes/ analog to understanding MANY chemical pathways working together. I once read in my arm chair studies - heh, that serotonin actually plays over 100 roles in the body, MOST in the intestines involved with messaging about food, same molecule ? yet so many uses in different contexts. Seeking too high or too low of a neurotransmitter might be like an English paper being returned and graded down because it had too many vowels.Tim Miltzhttps://www.blogger.com/profile/07606036610890811747noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-51247265271357448032010-12-22T03:11:26.935-05:002010-12-22T03:11:26.935-05:00For dietary mention, I once got a book on Sesame. ...For dietary mention, I once got a book on Sesame. All about sesame. <br /><br />Said it's the highest source of L-Tryptophan of any vegetables. It was also near the top on protein.<br /><br />Alas- Open Sesame ! <br /><br />no, really though, if you're after dietary loading up on Serotonin ? Don't forget about Sesame or tahini (ground sesame).<br /><br />For an interesting note ? Hummus ? made with Garbanzo beans ? I recall reading Garbanzo beans are high in levodopa. <br /><br />Bottom line, here is Hummus ? My view ? Offering a plethora of neurotransmitter support. I am convinced diet is CRITICAL in neurophysiological health, far more influencing than ANY Eli Lilly product. <br /><br />I find it interesting to learn that a small percentage of people ? can not absorb folate at ALL in their intestines, and some 50% of all people have trouble absording it.<br /><br />I recently found 5-Methyl tetrahydrofolate) -- 60 Vegetarian Capsules, you can find it - I can't promote any website it will detract from my point, heh, I have it on my wishlist, but I can't afford the $15.65, but I am want this for a methyl donor purpose in my own regiment I'm exploring. But I bring this up because I'd think 50% of people not absorbing folate WELL at all ? is a SERIOUS deficit. Who knows, maybe the 'feel good' nature of dopamine ? is tied into having the 5-Methyl tetrahydrofolate around. <br /><br />Ending up to realize I should get the 5MTHF ? Took a while after a good long evening of reading one article after another. <br /><br />I also recall reading some percentage of people- MOSTLY Middle Eastern lack this CytoChrome P450 enzymes, as in COMPLETELY lack it, I wrote a genetics expert who specializes in this, and he said they see typically 1 in 300,000 patients with this disorder - I'd think it's higher, I wrote saying, hey, shouldn't EVERYONE take this test before being given anything ? even a diphenhydramine ? I mean, imagine someone taking Nortryptaline having that condition, or Abilify, sure, they really could take 1/10th the capsule and save on bills ! (Eli Lilly wouldn't like that though, that cuts into profits), but I suspect before doing ANY studies on who takes this, and what happens ? I think there should be a BAR set - a STANDARD genetics clearing house on the data to make sure no one or no animals in any study ? comes in with a genetic bias. <br /><br />I learned that the FDA is requiring as of recent ? Such a test now for certaine drugs that would be broken down by Cyto P450, me ? I think EVERYONE should be tested for known genetic cicrumstances, even a Benadryl could cause someone harm if you're one of the unlucky ones. Maybe in time... Let's hope.Tim Miltzhttps://www.blogger.com/profile/07606036610890811747noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-39937744401440190922010-12-18T22:06:52.880-05:002010-12-18T22:06:52.880-05:00Todd, I did originally title the post "itchy ...Todd, I did originally title the post "itchy and scratchy" as a matter of fact ;)Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-87543808338262471822010-12-18T12:03:38.219-05:002010-12-18T12:03:38.219-05:00Oh, absolutely right. I hate it when I mess up si...Oh, absolutely right. I hate it when I mess up silly things.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-76424519305089377102010-12-18T12:00:37.956-05:002010-12-18T12:00:37.956-05:00"dextrose (which is two glucose molecules hoo..."dextrose (which is two glucose molecules hooked together)"<br /><br />That would be maltose. Dextrose is a single glucose molecule.Jim Boylehttps://www.blogger.com/profile/16299657396115615569noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-68968414275604006052010-12-17T20:40:18.041-05:002010-12-17T20:40:18.041-05:00Very interesting. Did you intend the title as a r...Very interesting. Did you intend the title as a reference to the Simpson's characters Itchy and Scratchy? No credit unless it was intentional ...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-30905472689134527732010-12-17T19:48:22.056-05:002010-12-17T19:48:22.056-05:00That's what they all say, Dr. Jaminet.That's what they all say, Dr. Jaminet.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-15490188811710475862010-12-17T19:36:25.061-05:002010-12-17T19:36:25.061-05:00Hi Emily,
I've been looking at this one also,...Hi Emily,<br /><br />I've been looking at this one also, see http://perfecthealthdiet.com/?p=1479. Please pay no mind to the psychiatrist-skepticism! Doesn't apply to you.<br /><br />I'm looking forward to your thoughts.<br /><br />Best, PaulPaul Jaminethttps://www.blogger.com/profile/15122941682076992645noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-75361467639889175092010-12-17T16:04:44.692-05:002010-12-17T16:04:44.692-05:00I thought for sure when I read the news reports ab...I thought for sure when I read the news reports about 8x the sugar that it was sucrose - but no - glucose - and the study confirmed the increased serotonin turnover by checking the actual brains.Anonymoushttps://www.blogger.com/profile/04429177284200775781noreply@blogger.comtag:blogger.com,1999:blog-3045634714760830992.post-70940237580663301532010-12-17T10:37:42.025-05:002010-12-17T10:37:42.025-05:00The control diet sure sounds like my childhood die...The control diet sure sounds like my childhood diet, except I had a lot more wheat in the form of bread, pasta, breakfast cereal and not as much corn. I remember always being fidgety, tapping my fingers and feet a lot, and going through bouts of facial ticks. Hmm...it's all starting to make sense. I'm actually a little surprised that a large increase in glucose caused the scratching and hair pulling. I would have guessed it was an increase in fructose that would have been responsible. A high starch diet (e.g., Kitavans) seems to be well handled by humans so long as the starches are from tubers which break down into glucose.Aaron Blaisdellhttps://www.blogger.com/profile/17204484453346358921noreply@blogger.com